分離済み変異体

tm2976

Allele Nametm2976
BalanceCompleted
OutCrossNot Accepted
Sequence NameM7.5
Gene Nameatg-7
Worm BaseAllele Name tm2976 (x1)
Gene Name atg-7
Sequence M7.5
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" lethal or sterile. Dr. H. Zhang: accumulation of several germline P granule components in somatic cells. Dr. O. Blacque: could not assess Dyf.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 310/311-CGCTTTTTTGC-572/573 (262 bp deletion + 11 bp insertion)
ChromosomeIV
Putative gene structurejoin(complement(929..1055), complement(713..879), complement(514..666),complement(106..463), complement(AL032641.1:18225..18397), complement(AL032641.1:17588..18181), complement(AL032641.1:17365..17535), complement(AL032641.1:17115..17315))
Map position4.83
BalancernT1,nT1 [qIs51]
Map position of balancer
Sequence of primersExtFwd:TCTGAGCTCCATCTGCTGAG,IntFwd:CTGCTGAGCATTCAGCACTC,ExtRev:TGGCGGTCTGAGAATCCTGA,IntRev:ATGGCCACGTTTGTTCCCTT
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Stavoe AK, Hill SE, Hall DH, Colón-Ramos DA.
KIF1A/UNC-104 Transports ATG-9 to Regulate Neurodevelopment and Autophagy at Synapses.
Dev Cell 2016 38(2) 171-85 
[ PubMed ID = 27396362 ] [ RRC reference ]

Erdélyi P, Borsos E, Takács-Vellai K, Kovács T, Kovács AL, Sigmond T, Hargitai B, Pásztor L, Sengupta T, Dengg M, Pécsi I, Tóth J, Nilsen H, Vértessy BG, Vellai T.
Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans.
J Cell Sci 2011 124(Pt 9) 1510-8 
[ PubMed ID = 21502138 ] [ RRC reference ]

Zhang Y, Yan L, Zhou Z, Yang P, Tian E, Zhang K, Zhao Y, Li Z, Song B, Han J, Miao L, Zhang H.
SEPA-1 mediates the specific recognition and degradation of P granule components by autophagy in C. elegans.
Cell 2009 136(2) 308-21 
[ PubMed ID = 19167332 ] [ RRC reference ]