Home > 分離済み変異体 > tm2918

分離済み変異体

Allele Name		tm2918
Balance		Not Required
OutCross		Not Accepted
Sequence Name		C17C3.19
Gene Name		ins-12
Worm Base	Allele Name	tm2918
	Gene Name	ins-12
	Sequence	C17C3.19
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable. Dr. T. Katada: No abnormal proliferation in Z2/Z3 cells during L1 diapause. Dr. Q.L. Ch'ng: normal locomotion and egg-laying. Dr. J. Kaplan: weak Hic, increased Nile Red staining. Dr. P.W. Sternberg: normal locomotion.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		24667/24668-25121/25122 (454 bp deletion)
Chromosome		II
Putative gene structure		join(24520..24669, 25087..25197)
Map position		-1.15
Balancer
Map position of balancer
Sequence of primers		IntFwd:TTCCTTTAGGCGTTCTCTAG,ExtFwd:GGTCACTTCGAACTGTCCTT,IntRev:GGTTGGATCTTCAAGGTCGG,ExtRev:TAAGCATCAGTGACGGTGAT
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Burton NO, Furuta T, Webster AK, Kaplan RE, Baugh LR, Arur S, Horvitz HR. Insulin-like signalling to the maternal germline controls progeny response to osmotic stress. Nat Cell Biol 2017 19(3) 252-257  [ PubMed ID = 28166192 ] [ RRC reference ] Fernandes de Abreu DA, Caballero A, Fardel P, Stroustrup N, Chen Z, Lee K, Keyes WD, Nash ZM, López-Moyado IF, Vaggi F, Cornils A, Regenass M, Neagu A, Ostojic I, Liu C, Cho Y, Sifoglu D, Shen Y, Fontana W, Lu H, Csikasz-Nagy A, Murphy CT, Antebi A, Blanc E, Apfeld J, Zhang Y, Alcedo J, Ch'ng Q. An insulin-to-insulin regulatory network orchestrates phenotypic specificity in development and physiology. PLoS Genet 2014 10(3) e1004225  [ PubMed ID = 24675767 ] [ RRC reference ] Hung WL, Hwang C, Gao S, Liao EH, Chitturi J, Wang Y, Li H, Stigloher C, Bessereau JL, Zhen M. Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development. EMBO J 2013 32(12) 1745-60  [ PubMed ID = 23665919 ] [ RRC reference ]