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分離済み変異体

Allele Name		tm2912
Balance		Completed
OutCross		Not Accepted
Sequence Name		F02E8.3
Gene Name		aps-2
Worm Base	Allele Name	tm2912 (x1)
	Gene Name	aps-2
	Sequence	F02E8.3
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		lethal or sterile. Dr. O. Blacque: could not assess Dyf phenotype due to lethality.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		11246/11247-11440/11441 (194 bp deletion)
Chromosome		X
Putative gene structure		join(10598..10684, 10736..10915, 11285..11446)
Map position		-7.58
Balancer		egl-17(e1313) lon-2(e678) X
Map position of balancer
Sequence of primers		ExtRev:CTTAGAATACCTCCGGCAAC,ExtFwd:GCGGATTTCAGCTTTCCGCA,IntFwd:CCGCAAGGTCTTCGCTAAGT,IntRev:GAATACCTCCGGCAACATTG
Distributed lab
Depositor		Dr. S. Mitani
References		Please submit your publication Garafalo SD, Luth ES, Moss BJ, Monteiro MI, Malkin E, Juo P. The AP2 clathrin adaptor protein complex regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of Caenorhabditis elegans. Mol Biol Cell 2015 26(10) 1887-900  [ PubMed ID = 25788288 ] [ RRC reference ] Hollopeter G, Lange JJ, Zhang Y, Vu TN, Gu M, Ailion M, Lambie EJ, Slaughter BD, Unruh JR, Florens L, Jorgensen EM. The membrane-associated proteins FCHo and SGIP are allosteric activators of the AP2 clathrin adaptor complex. Elife 2014 3   [ PubMed ID = 25303366 ] [ RRC reference ] Wang L, Audhya A. In vivo imaging of C. elegans endocytosis. Methods 2014 68(3) 518-28  [ PubMed ID = 24704355 ] [ RRC reference ] Kuwahara T, Koyama A, Koyama S, Yoshina S, Ren CH, Kato T, Mitani S, Iwatsubo T. A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in alpha-synuclein transgenic C. elegans. Hum Mol Genet 2008 17(19) 2997-3009  [ PubMed ID = 18617532 ] [ RRC reference ]