分離済み変異体

tm2877

Allele Nametm2877
BalanceNot Required
OutCrossNot Accepted
Sequence NameC43H6.9
Gene Nameglr-7
Worm BaseAllele Name tm2877
Gene Name glr-7
Sequence C43H6.9
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" homozygous viable. Dr. K. Ashrafi: wild-type Nile Red staining. Dr. I. Mori: normal thermotaxix at 20C.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 19770/19771-CTCTCTGATGCGCTTCCTT-20253/20254 (483 bp deletion + 19 bp insertion)
ChromosomeX
Putative gene structurecomplement(join(18684..19049, 19542..19745, 19798..19930, 19977..20167, 20215..20325, 20383..20521, 21268..21347, 21395..21843, 21892..22059, 22115..22324, 22376..22537, 22617..[T07D1]1015))
Map position-15.56
Balancer
Map position of balancer
Sequence of primersExtFwd:AACACAGCCTGAGCCCAGTC,IntFwd:TCATCCGATGAGTCAGGGCA,ExtRev:GGGAGTAAGCTATAGCACTG,IntRev:TTCCGGCCGTTTGGTTGCTG
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Wen X, Chen YH, Li R, Ge MH, Yin SW, Wu JJ, Huang JH, Liu H, Wang PZ, Gross E, Wu ZX.
Signal Decoding for Glutamate Modulating Egg Laying Oppositely in Caenorhabditiselegans under Varied Environmental Conditions.
iScience 2020 23(10) 101588 
[ PubMed ID = 33089099 ] [ RRC reference ]

Bhatla N, Droste R, Sando SR, Huang A, Horvitz HR.
Distinct Neural Circuits Control Rhythm Inhibition and Spitting by the Myogenic Pharynx of C. elegans.
Curr Biol 2015 25(16) 2075-89 
[ PubMed ID = 26212880 ] [ RRC reference ]

Hardaway JA, Sturgeon SM, Snarrenberg CL, Li Z, Xu XZ, Bermingham DP, Odiase P, Spencer WC, Miller DM 3rd, Carvelli L, Hardie SL, Blakely RD.
Glial Expression of the Caenorhabditis elegans Gene swip-10 Supports Glutamate Dependent Control of Extrasynaptic Dopamine Signaling.
J Neurosci 2015 35(25) 9409-23 
[ PubMed ID = 26109664 ] [ RRC reference ]

Cunningham KA, Hua Z, Srinivasan S, Liu J, Lee BH, Edwards RH, Ashrafi K.
AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans.
Cell Metab 2012 16(1) 113-21 
[ PubMed ID = 22768843 ] [ RRC reference ]

Li Z, Li Y, Yi Y, Huang W, Yang S, Niu W, Zhang L, Xu Z, Qu A, Wu Z, Xu T.
Dissecting a central flip-flop circuit that integrates contradictory sensory cues in C. elegans feeding regulation.
Nat Commun 2012 3 776 
[ PubMed ID = 22491324 ] [ RRC reference ]