分離済み変異体

tm2868

Allele Nametm2868
BalanceNot Required
OutCrossNot Accepted
Sequence NameC27A2.1
Gene Namesmc-5
Worm BaseAllele Name tm2868
Gene Name smc-5
Sequence C27A2.1
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" homozygous viable.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 10345/10346-10790/10791 (445 bp deletion)
ChromosomeII
Putative gene structurejoin(9407..9498, 9547..9741, 9797..9929, 9974..10438, 10485..10812, 10861..11012, 11923..12315, 12365..12514, 12563..12838, 13101..13379, 13426..14133, 14181..14240)
Map position-2.55
Balancer
Map position of balancer
Sequence of primersIntFwd:GCTCATTACCAGATCGCACT,ExtFwd:TTATCGCCTAGAGCTCAGCT,ExtRev:GGGCATATATACGTCTCCTT,IntRev:GTTGATACCAGCGATAGGCT
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Mazzetto M, Gonzalez LE, Sanchez N, Reinke V.
Characterization of the distribution and dynamics of chromatin states in the C. elegans germline reveals substantial H3K4me3 remodeling during oogenesis.
Genome Res 2024 34(1) 57-69 
[ PubMed ID = 38164610 ] [ RRC reference ]

Hong Y, Sonneville R, Agostinho A, Meier B, Wang B, Blow JJ, Gartner A.
The SMC-5/6 Complex and the HIM-6 (BLM) Helicase Synergistically Promote Meiotic Recombination Intermediate Processing and Chromosome Maturation during Caenorhabditis elegans Meiosis.
PLoS Genet 2016 12(3) e1005872 
[ PubMed ID = 27010650 ] [ RRC reference ]

Bickel JS, Chen L, Hayward J, Yeap SL, Alkers AE, Chan RC.
Structural maintenance of chromosomes (SMC) proteins promote homolog-independent recombination repair in meiosis crucial for germ cell genomic stability.
PLoS Genet 2010 6(7) e1001028 
[ PubMed ID = 20661436 ] [ RRC reference ]