分離済み変異体

tm2706

Allele Nametm2706
BalanceNot Required
OutCrossNot Accepted
Sequence NameK02G10.4a
Gene Nameflp-11
Worm BaseAllele Name tm2706
Gene Name flp-11
Sequence K02G10.4a
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" homozygous viable
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 4360/4361-4514/4515 (154 bp deletion)
ChromosomeX
Putative gene structurecomplement(join(4206..4291, 4361..4527, 4583..4662))
Map position-6.9
Balancer
Map position of balancer
Sequence of primersIntRev:GCATTGGCACTTCTCCTTAT,ExtRev:ACGCCCCCTCCTAATACATC,IntFwd:GGTCGTCCTCGGTCATTACT,ExtFwd:TCGCCTCAGGAGTTGTTCGA
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Uegaki R, Maega S, Ono M, Bito T, Iwasaki T, Shiraishi A, Satake H, Kawano T.
The FMRFamide-like peptide FLP-11 regulates the production and secretion of the TGF-β-like protein DAF-7 during Caenorhabditis elegans larval development.
Sci Rep 2026 16(1) 4634 
[ PubMed ID = 41501349 ] [ RRC reference ]

Le TA, Temmerman L, Roy C.
Nictation behavior in nematodes.
BMC Biol 2025 23(1) 356 
[ PubMed ID = 41350688 ] [ RRC reference ]

Rossi L, Amoako K, Busack I, Golinelli L, Courtney A, Besseling J, Schafer W, Beets I, Bringmann H.
The neuropeptide FLP-11 induces and self-inhibits sleep through the receptor DMSR-1 in Caenorhabiditis elegans.
Curr Biol 2025 35(9) 2183-2194.e10 
[ PubMed ID = 40273913 ] [ RRC reference ]

Wang PZ, Ge MH, Su P, Wu PP, Wang L, Zhu W, Li R, Liu H, Wu JJ, Xu Y, Zhao JL, Li SJ, Wang Y, Chen LM, Wu TH, Wu ZX.
Sensory plasticity caused by up-down regulation encodes the information of short-term learning and memory.
iScience 2025 28(4) 112215 
[ PubMed ID = 40224011 ] [ RRC reference ]

Subramanian S, Diya N, Nelson MD.
Egg laying during stress-induced sleep of Caenorhabditis elegans is reduced due to behavioral quiescence and fertility defects.
MicroPubl Biol 2025 2025  
[ PubMed ID = 40741294 ] [ RRC reference ]

Iannacone MJ, Um P, Grubbs JI, van der Linden AM, Raizen DM.
Quiescence Enhances Survival during Viral Infection in Caenorhabditis elegans.
J Neurosci 2024 44(35)  
[ PubMed ID = 39060176 ] [ RRC reference ]

Ji H, Fouad AD, Li Z, Ruba A, Fang-Yen C.
A proprioceptive feedback circuit drives Caenorhabditis elegans locomotor adaptation through dopamine signaling.
Proc Natl Acad Sci U S A 2023 120(20) e2219341120 
[ PubMed ID = 37155851 ] [ RRC reference ]

Busack I, Bringmann H.
A sleep-active neuron can promote survival while sleep behavior is disturbed.
PLoS Genet 2023 19(3) e1010665 
[ PubMed ID = 36917595 ] [ RRC reference ]

Cockx B, Van Bael S, Boelen R, Vandewyer E, Yang H, Le TA, Dalzell JJ, Beets I, Ludwig C, Lee J, Temmerman L.
Mass Spectrometry-Driven Discovery of Neuropeptides Mediating Nictation Behavior of Nematodes.
Mol Cell Proteomics 2023 22(2) 100479 
[ PubMed ID = 36481452 ] [ RRC reference ]

Ren J, Sang Y, Aballay A.
Cholinergic receptor-Wnt pathway controls immune activation by sensing intestinal dysfunction.
Cell Rep 2022 41(5) 111575 
[ PubMed ID = 36323254 ] [ RRC reference ]

Ardiel EL, Lauziere A, Xu S, Harvey BJ, Christensen RP, Nurrish S, Kaplan JM, Shroff H.
Stereotyped behavioral maturation and rhythmic quiescence in C. elegans embryos.
Elife 2022 11  
[ PubMed ID = 35929725 ] [ RRC reference ]

Bayer EA, Liberatore KM, Schneider JR, Schlesinger E, He Z, Birnbaum S, Wightman B.
Insulin signaling and osmotic stress response regulate arousal and developmental progression of C. elegans at hatching.
Genetics 2022 220(1)  
[ PubMed ID = 34788806 ] [ RRC reference ]

Makino M, Ulzii E, Shirasaki R, Kim J, You YJ.
Regulation of Satiety Quiescence by Neuropeptide Signaling in Caenorhabditis elegans.
Front Neurosci 2021 15 678590 
[ PubMed ID = 34335159 ] [ RRC reference ]

Maluck E, Busack I, Besseling J, Masurat F, Turek M, Busch KE, Bringmann H.
A wake-active locomotion circuit depolarizes a sleep-active neuron to switch on sleep.
PLoS Biol 2020 18(2) e3000361 
[ PubMed ID = 32078631 ] [ RRC reference ]

Steuer Costa W, Van der Auwera P, Glock C, Liewald JF, Bach M, Schüler C, Wabnig S, Oranth A, Masurat F, Bringmann H, Schoofs L, Stelzer EHK, Fischer SC, Gottschalk A.
A GABAergic and peptidergic sleep neuron as a locomotion stop neuron with compartmentalized Ca2+ dynamics.
Nat Commun 2019 10(1) 4095 
[ PubMed ID = 31506439 ] [ RRC reference ]

Chew YL, Tanizawa Y, Cho Y, Zhao B, Yu AJ, Ardiel EL, Rabinowitch I, Bai J, Rankin CH, Lu H, Beets I, Schafer WR.
An Afferent Neuropeptide System Transmits Mechanosensory Signals Triggering Sensitization and Arousal in C. elegans.
Neuron 2018 99(6) 1233-1246.e6 
[ PubMed ID = 30146306 ] [ RRC reference ]

Lee JS, Shih PY, Schaedel ON, Quintero-Cadena P, Rogers AK, Sternberg PW.
FMRFamide-like peptides expand the behavioral repertoire of a densely connected nervous system.
Proc Natl Acad Sci U S A 2017 114(50) E10726-E10735 
[ PubMed ID = 29167374 ] [ RRC reference ]

Banerjee N, Bhattacharya R, Gorczyca M, Collins KM, Francis MM.
Local neuropeptide signaling modulates serotonergic transmission to shape the temporal organization of C. elegans egg-laying behavior.
PLoS Genet 2017 13(4) e1006697 
[ PubMed ID = 28384151 ] [ RRC reference ]

Turek M, Besseling J, Spies JP, König S, Bringmann H.
Sleep-active neuron specification and sleep induction require FLP-11 neuropeptides to systemically induce sleep.
Elife 2016 5  
[ PubMed ID = 26949257 ] [ RRC reference ]

Yemini E, Jucikas T, Grundy LJ, Brown AE, Schafer WR.
A database of Caenorhabditis elegans behavioral phenotypes.
Nat Methods 2013 10(9) 877-9 
[ PubMed ID = 23852451 ] [ RRC reference ]