分離済み変異体

tm2697

Allele Nametm2697
BalanceCompleted
OutCrossNot Accepted
Sequence NameZK1128.2
Gene Namemett-10
Worm BaseAllele Name tm2697
Gene Name mett-10
Sequence ZK1128.2
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" lethal or sterile. Dr. T. Schedl: in frame deletion. Strain is a ts sterile/Pvl. At 20 C, the strain is fertile with about 10% penetrance of the Pvl. At 25 C, the strain is 100% sterile, with close to 90% penetrance of the Pvl.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 4946/4947-5503/5504 (557 bp deletion)
ChromosomeIII
Putative gene structurejoin(4106..4306, 4377..4676, 4731..4996, 5047..5215, 5264..5767)
Map position1.84
BalancerhT2 [bli-4(e937) let-? qIs48]
Map position of balancer
Sequence of primersIntFwd:GCGATGCATAACCGGGTGGT,ExtRev:GCACTAGTTGATGAAGGTGT,IntRev:GAATGATCGGGCCAGGAACT,ExtFwd:CAACTGTGATCGGCCCGGAA
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Mazzetto M, Gonzalez LE, Sanchez N, Reinke V.
Characterization of the distribution and dynamics of chromatin states in the C. elegans germline reveals substantial H3K4me3 remodeling during oogenesis.
Genome Res 2024 34(1) 57-69 
[ PubMed ID = 38164610 ] [ RRC reference ]

Dorsett M, Schedl T.
A role for dynein in the inhibition of germ cell proliferative fate.
Mol Cell Biol 2009 29(22) 6128-39 
[ PubMed ID = 19752194 ] [ RRC reference ]

Dorsett M, Westlund B, Schedl T.
METT-10, a putative methyltransferase, inhibits germ cell proliferative fate in Caenorhabditis elegans.
Genetics 2009 183(1) 233-47 
[ PubMed ID = 19596901 ] [ RRC reference ]