Home > 分離済み変異体 > tm2692

分離済み変異体

Allele Name		tm2692
Balance		Not Required
OutCross		Not Accepted
Sequence Name		T09B4.10
Gene Name		chn-1
Worm Base	Allele Name	tm2692
	Gene Name	chn-1
	Sequence	T09B4.10
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		33772/33773-AGC-34035/34036 (263 bp deletion + 3 bp insertion)
Chromosome		I
Putative gene structure		complement(join(31986..32048, 33044..33256, 33478..33684, 33732..33830, 33879..33947, 34001..34091, 34138..34196))
Map position		0.88
Balancer
Map position of balancer
Sequence of primers		ExtFwd:CCGCAGAGCATCTCAGGAAC,IntFwd:CCGCTAAAGTGAGTTCGGTT,ExtRev:CAGAGCTTACGCGCAACTCT,IntRev:ATGTCAAGCGGCGCCGAACA
Distributed lab
Depositor		Dr. S. Mitani
References		Please submit your publication Earnshaw R, Zhang YT, Heymann G, Fujisawa K, Hui S, Kapadia M, Kalia LV, Kalia SK. Disease-associated mutations in C-terminus of HSP70 interacting protein (CHIP) impair its ability to negatively regulate mitophagy. Neurobiol Dis 2024 200 106625  [ PubMed ID = 39117117 ] [ RRC reference ] Liu J, Li M, Li L, Chen S, Wang X. Ubiquitination of the PI3-kinase VPS-34 promotes VPS-34 stability and phagosome maturation. J Cell Biol 2018 217(1) 347-360  [ PubMed ID = 29092895 ] [ RRC reference ] Tawo R, Pokrzywa W, Kevei É, Akyuz ME, Balaji V, Adrian S, Höhfeld J, Hoppe T. The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover. Cell 2017 169(3) 470-482.e13  [ PubMed ID = 28431247 ] [ RRC reference ]