分離済み変異体

tm2673

Allele Nametm2673
Allele Type通常株
Sequence NameF46G10.7
Gene Namesir-2.2
Worm BaseAllele Name tm2673
Gene Name sir-2.2
Sequence F46G10.7
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" homozygous viable. Dr. C-S. Chen: normal sensitivity to Bacillus pore-forming toxin.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 21539/21540-22087/22088 (548 bp deletion)
ChromosomeX
Putative gene structurejoin(21078..21204, 21254..21356, 21574..21714, 21758..21838, 22298..22412, 22459..22641, 22803..22916)
Map position11.32
Balancer
Map position of balancer
Sequence of primersExtFwd:AACAGTGGACAAGCTGCTTG,IntRev:GATTGTCTGCCATTCCACAC,IntFwd:CTTGTCATCTCTGGAGCAGG,ExtRev:GCGTCCATACTCTCTTAGAT
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Wirth M, Karaca S, Wenzel D, Ho L, Tishkoff D, Lombard DB, Verdin E, Urlaub H, Jedrusik-Bode M, Fischle W.
Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases.
Mitochondrion 2013 13(6) 705-20 
[ PubMed ID = 23438705 ] [ RRC reference ]

Wang W, McReynolds MR, Goncalves JF, Shu M, Dhondt I, Braeckman BP, Lange SE, Kho K, Detwiler AC, Pacella MJ, Hanna-Rose W.
Comparative Metabolomic Profiling Reveals That Dysregulated Glycolysis Stemming from Lack of Salvage NAD+ Biosynthesis Impairs Reproductive Development in Caenorhabditis elegans.
J Biol Chem 2015 290(43) 26163-79 
[ PubMed ID = 26350462 ] [ RRC reference ]