分離済み変異体

tm2664

Allele Nametm2664
BalanceCompleted
OutCrossNot Accepted
Sequence NameT04H1.4
Gene Namerad-50
Worm BaseAllele Name tm2664 (x1)
Gene Name rad-50
Sequence T04H1.4
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" lethal or sterile
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 14617/14618-15033/15034 (416 bp deletion)
ChromosomeV
Putative gene structurejoin(12307..12324, 12380..12490, 12538..12618, 12662..12763, 12818..13099, 13146..13365, 13413..13663, 13713..14843, 14901..15580, 15632..16174, 16230..16542, 16586..16750)
Map position3.92
BalancernT1 [qIs51]
Map position of balancer
Sequence of primersIntRev:GTAGCTGAGGCCATCCGAAG,ExtRev:CGAAGTTCGGTGTAGCTGAG,IntFwd:AGGGATAAACTGGTCGCTAG,ExtFwd:CGAGACTCATGTTAGGGATA
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Thapa P, Chikale RV, Szulc NA, Pandrea MT, Sztyler A, Jaggi K, Niklewicz M, Serwa RA, Hoppe T, Pokrzywa W.
HSP70 inhibits CHIP E3 ligase activity to maintain germline function in Caenorhabditis elegans.
J Biol Chem 2024 300(11) 107864 
[ PubMed ID = 39384041 ] [ RRC reference ]

Mazzetto M, Gonzalez LE, Sanchez N, Reinke V.
Characterization of the distribution and dynamics of chromatin states in the C. elegans germline reveals substantial H3K4me3 remodeling during oogenesis.
Genome Res 2024 34(1) 57-69 
[ PubMed ID = 38164610 ] [ RRC reference ]