分離済み変異体

tm2660

Allele Nametm2660
BalanceNot Required
OutCrossNot Accepted
Sequence NameH21P03.3
Gene Namesms-1
Worm BaseAllele Name tm2660
Gene Name sms-1
Sequence H21P03.3
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" homozygous viable.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 6192/6193-6729/6730 (537 bp deletion)
ChromosomeIV
Putative gene structurecomplement(join(3229..3974, 4522..4697, 4981..5270, 5920..6298, 6459..6668, 16839..16922, 16839..16922))
Map position4.99
Balancer
Map position of balancer
Sequence of primersIntRev:TTGGCTATTCACTCCACCCT,ExtRev:TGATCGGTTATTGTGGTGGT,IntFwd:TCGAAGTCCCCATGGAATCT,ExtFwd:CCCTAGCTTAATGGTGTCAT
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Guzman G, Jahn H, Farley SE, Kyle JE, Bramer LM, Hoetzl S, van den Dikkenberg J, Hermansson M, Holthuis JCM, Tafesse FG.
Characterization of Caenorhabditis elegans sphingomyelin synthases through heterologous expression.
J Biol Chem 2025 301(7) 110300 
[ PubMed ID = 40473211 ] [ RRC reference ]

Hao L, Ben-David O, Babb SM, Futerman AH, Cohen BM, Buttner EA.
Clozapine Modulates Glucosylceramide, Clears Aggregated Proteins, and Enhances ATG8/LC3 in Caenorhabditis elegans.
Neuropsychopharmacology 2017 42(4) 951-962 
[ PubMed ID = 27711049 ] [ RRC reference ]

Cui M, Wang Y, Cavaleri J, Kelson T, Teng Y, Han M.
Starvation-Induced Stress Response Is Critically Impacted by Ceramide Levels in Caenorhabditis elegans.
Genetics 2017 205(2) 775-785 
[ PubMed ID = 27974500 ] [ RRC reference ]