分離済み変異体

tm2569

Allele Name

tm2569

Balance

Not Required

OutCross

Not Accepted

Sequence Name

Y47D3B.2

Gene Name

nlp-21

Worm Base

Allele Name

tm2569

Gene Name

nlp-21

Sequence

Y47D3B.2

Phenotype

homozygous viable. Dr. J. Kaplan: Ric. Dr. Z-X. Wu: normal chemotaxis against glycerol, Cu and normal nose touch response. Dr. I. Mori: normal thermotaxis at 20C.

Mutation site

13461/13462-13806/13807 (345 bp deletion)

Chromosome

III

Putative gene structure

complement(join(12895..12950, 13560..13955, 17307..17349))

Map position

9.09

Balancer

Map position of balancer

Sequence of primers

IntRev:TGTACTCCCACTGCTCTATT,ExtFwd:TCTAGCCATGGAATCCTTGT,IntFwd:CACATGGCACATGGTGCAAC,ExtRev:GAGAGGTTGTATCTCGGTTG

Distributed lab

Depositor

Dr. S. Mitani/NBRP

References

Please submit your publication

Shao J, Liewald JF, Steuer Costa W, Ruse C, Gruber J, Djamshedzad MS, Gebhardt W, Gottschalk A.
Loss of neuropeptidergic regulation of cholinergic transmission induces homeostatic compensation in muscle cells to preserve synaptic strength.
PLoS Biol 2025 23(5) e3003171
[ PubMed ID = 40338987 ] [ RRC reference ]

Wang PZ, Ge MH, Su P, Wu PP, Wang L, Zhu W, Li R, Liu H, Wu JJ, Xu Y, Zhao JL, Li SJ, Wang Y, Chen LM, Wu TH, Wu ZX.
Sensory plasticity caused by up-down regulation encodes the information of short-term learning and memory.
iScience 2025 28(4) 112215
[ PubMed ID = 40224011 ] [ RRC reference ]

Chen YC, Zang KE, Ahamed H, Ringstad N.
Food sensing controls C. elegans reproductive behavior by neuromodulatory disinhibition.
Sci Adv 2025 11(16) eadu5829
[ PubMed ID = 40238881 ] [ RRC reference ]

Xue W, Chen Y, Lei Z, Wang Y, Liu J, Wen X, Xu F, Chen P, Wu Z, Jin YN, Yu YV.
Calcium levels in ASER neurons determine behavioral valence by engaging distinct neuronal circuits in C. elegans.
Nat Commun 2025 16(1) 1814
[ PubMed ID = 39979341 ] [ RRC reference ]

Nakayama A, Watanabe M, Yamashiro R, Kuroyanagi H, Matsuyama HJ, Oshima A, Mori I, Nakano S.
A hyperpolarizing neuron recruits undocked innexin hemichannels to transmit neural information in Caenorhabditis elegans.
Proc Natl Acad Sci U S A 2024 121(21) e2406565121
[ PubMed ID = 38753507 ] [ RRC reference ]

Fay DS, Polley SR, Kuang J, Kuzmanov A, Hazel JW, Mani K, Veo BL, Yochem J.
A regulatory module controlling pharyngeal development and function in Caenorhabditis elegans.
Genetics 2012 191(3) 827-43
[ PubMed ID = 22542967 ] [ RRC reference ]