Home > 分離済み変異体 > tm2504

分離済み変異体

Allele Name		tm2504
Balance		Completed
OutCross		Not Accepted
Sequence Name		Y57G11C.13
Gene Name		arl-8
Worm Base	Allele Name	tm2504 (x1)
	Gene Name	arl-8
	Sequence	Y57G11C.13
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		lethal or sterile
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		161377/161378-161657/161658 (280 bp deletion)
Chromosome		IV
Putative gene structure		join(160907..161029, 161078..161465, 161513..161559)
Map position		12.52
Balancer		nT1 [qIs51]
Map position of balancer
Sequence of primers		ExtRev:ATTAGGCTGCAATGCTAGAG,IntRev:CATCCCACAGTGAAAGCTAC,ExtFwd:CTCGACTGGATTCGCAGTCT,IntFwd:CTTTAGAGCGGCCAATTCAC
Distributed lab
Depositor		Dr. S. Mitani
References		Please submit your publication Fazeli G, Levin-Konigsberg R, Bassik MC, Stigloher C, Wehman AM. A BORC-dependent molecular pathway for vesiculation of cell corpse phagolysosomes. Curr Biol 2023 33(4) 607-621.e7  [ PubMed ID = 36652947 ] [ RRC reference ] Delahaye JL, Foster OK, Vine A, Saxton DS, Curtin TP, Somhegyi H, Salesky R, Hermann GJ. Caenorhabditis elegans HOPS and CCZ-1 mediate trafficking to lysosome-related organelles independently of RAB-7 and SAND-1. Mol Biol Cell 2014 25(7) 1073-96  [ PubMed ID = 24501423 ] [ RRC reference ] Sasaki A, Nakae I, Nagasawa M, Hashimoto K, Abe F, Saito K, Fukuyama M, Gengyo-Ando K, Mitani S, Katada T, Kontani K. Arl8/ARL-8 functions in apoptotic cell removal by mediating phagolysosome formation in Caenorhabditis elegans. Mol Biol Cell 2013 24(10) 1584-92  [ PubMed ID = 23485564 ] [ RRC reference ] Nakae I, Fujino T, Kobayashi T, Sasaki A, Kikko Y, Fukuyama M, Gengyo-Ando K, Mitani S, Kontani K, Katada T. The arf-like GTPase Arl8 mediates delivery of endocytosed macromolecules to lysosomes in Caenorhabditis elegans. Mol Biol Cell 2010 21(14) 2434-42  [ PubMed ID = 20484575 ] [ RRC reference ] Klassen MP, Wu YE, Maeder CI, Nakae I, Cueva JG, Lehrman EK, Tada M, Gengyo-Ando K, Wang GJ, Goodman M, Mitani S, Kontani K, Katada T, Shen K. An Arf-like small G protein, ARL-8, promotes the axonal transport of presynaptic cargoes by suppressing vesicle aggregation. Neuron 2010 66(5) 710-23  [ PubMed ID = 20547129 ] [ RRC reference ]