分離済み変異体

tm2469

Allele Name

tm2469

Balance

Completed

OutCross

Not Accepted

Sequence Name

R08C7.3

Gene Name

htz-1

Worm Base

Allele Name

tm2469 (x1)

Gene Name

htz-1

Sequence

R08C7.3

Phenotype

lethal or sterile. Dr. W.G. Kelly: fertile and histone methylation on the male X chromosome is normal. Dr. H. Sawa: no Psa phenotype. Dr. M. Han: Ste.

Mutation site

25290/25291-25635/25636 (345 bp deletion)

Chromosome

Putative gene structure

join(25174..25343, 25394..25646)

Map position

0.28

Balancer

nT1 [qIs51]

Map position of balancer

Sequence of primers

ExtFwd:GCGTGCCAAAAAGGAGGAGT,IntFwd:GCGCGCTTTTGAGAGTTGAT,ExtRev:CGCCTATTGGGGAGTGATAG,IntRev:CCAGCATTTATTGTGGTCCT

Distributed lab

Depositor

Dr. S. Mitani/NBRP

References

Please submit your publication

Mazzetto M, Gonzalez LE, Sanchez N, Reinke V.
Characterization of the distribution and dynamics of chromatin states in the C. elegans germline reveals substantial H3K4me3 remodeling during oogenesis.
Genome Res 2024 34(1) 57-69
[ PubMed ID = 38164610 ] [ RRC reference ]

Negishi T, Kitagawa S, Horii N, Tanaka Y, Haruta N, Sugimoto A, Sawa H, Hayashi KI, Harata M, Kanemaki MT.
The auxin-inducible degron 2 (AID2) system enables controlled protein knockdown during embryogenesis and development in Caenorhabditis elegans.
Genetics 2022 220(2)
[ PubMed ID = 34865044 ] [ RRC reference ]

Shibata Y, Sawa H, Nishiwaki K.
HTZ-1/H2A.z and MYS-1/MYST HAT act redundantly to maintain cell fates in somatic gonadal cells through repression of ceh-22 in C. elegans.
Development 2014 141(1) 209-18
[ PubMed ID = 24346701 ] [ RRC reference ]

Petty E, Laughlin E, Csankovszki G.
Regulation of DCC localization by HTZ-1/H2A.Z and DPY-30 does not correlate with H3K4 methylation levels.
PLoS One 2011 6(10) e25973
[ PubMed ID = 21998734 ] [ RRC reference ]

Wagner CR, Kuervers L, Baillie DL, Yanowitz JL.
xnd-1 regulates the global recombination landscape in Caenorhabditis elegans.
Nature 2010 467(7317) 839-43
[ PubMed ID = 20944745 ] [ RRC reference ]

Petty EL, Collette KS, Cohen AJ, Snyder MJ, Csankovszki G.
Restricting dosage compensation complex binding to the X chromosomes by H2A.Z/HTZ-1.
PLoS Genet 2009 5(10) e1000699
[ PubMed ID = 19851459 ] [ RRC reference ]

Whittle CM, McClinic KN, Ercan S, Zhang X, Green RD, Kelly WG, Lieb JD.
The genomic distribution and function of histone variant HTZ-1 during C. elegans embryogenesis.
PLoS Genet 2008 4(9) e1000187
[ PubMed ID = 18787694 ] [ RRC reference ]