分離済み変異体

tm2417

Allele Nametm2417
BalanceCompleted
OutCrossNot Accepted
Sequence NameY23H5A.3
Gene NameY23H5A.3
Worm BaseAllele Name tm2417 (x1)
Gene Name Y23H5A.3
Sequence Y23H5A.3
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" lethal or sterile
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 14492/14493-C-14836/14837 (344 bp deletion + 1 bp insertion)
ChromosomeI
Putative gene structurejoin(13966..14130, 14178..14255, 14302..14531, 14591..15041)
Map position-8.14
BalancerhT2 [bli-4(e937) let-? qIs48]
Map position of balancer
Sequence of primersExtFwd:AGCCATTTTCAAACGCGGGA,IntRev:GCACGGCCTGATAGACTTGA,ExtRev:ATCCTGCACGGCCTGATAGA,IntFwd:ATGGGCGATGGTCGTGACTG
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Mazzetto M, Gonzalez LE, Sanchez N, Reinke V.
Characterization of the distribution and dynamics of chromatin states in the C. elegans germline reveals substantial H3K4me3 remodeling during oogenesis.
Genome Res 2024 34(1) 57-69 
[ PubMed ID = 38164610 ] [ RRC reference ]

Wang X, Zeng C, Liao S, Zhu Z, Zhang J, Tu X, Yao X, Feng X, Guang S, Xu C.
Molecular basis for PICS-mediated piRNA biogenesis and cell division.
Nat Commun 2021 12(1) 5595 
[ PubMed ID = 34552083 ] [ RRC reference ]

Cordeiro Rodrigues RJ, de Jesus Domingues AM, Hellmann S, Dietz S, de Albuquerque BFM, Renz C, Ulrich HD, Sarkies P, Butter F, Ketting RF.
PETISCO is a novel protein complex required for 21U RNA biogenesis and embryonic viability.
Genes Dev 2019 33(13-14) 857-870 
[ PubMed ID = 31147388 ] [ RRC reference ]

Zeng C, Weng C, Wang X, Yan YH, Li WJ, Xu D, Hong M, Liao S, Dong MQ, Feng X, Xu C, Guang S.
Functional Proteomics Identifies a PICS Complex Required for piRNA Maturation and Chromosome Segregation.
Cell Rep 2019 27(12) 3561-3572.e3 
[ PubMed ID = 31216475 ] [ RRC reference ]