Home > 分離済み変異体 > tm2388

分離済み変異体

Allele Name		tm2388
Balance		Not Required
OutCross		Not Accepted
Sequence Name		Y57G11C.13
Gene Name		arl-8
Worm Base	Allele Name	tm2388
	Gene Name	arl-8
	Sequence	Y57G11C.13
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		161589/161590-161962/161963 (373 bp deletion)
Chromosome		IV
Putative gene structure		join(160907..161029, 161078..161465, 161513..161559)
Map position		12.52
Balancer
Map position of balancer
Sequence of primers		IntRev:ATTAGGCTGCAATGCTAGAG,ExtRev:GCAACAGTTCCCGAATCGCT,ExtFwd:CGCTATTCCAGTTTTGGTGC,IntFwd:CAAGAAGGATTTGCCTGGAG
Distributed lab
Depositor		Dr. S. Mitani
References		Please submit your publication Balseiro-Gómez S, Park J, Yue Y, Ding C, Shao L, Ҫetinkaya S, Kuzoian C, Hammarlund M, Verhey KJ, Yogev S. Neurexin and frizzled intercept axonal transport at microtubule minus ends to control synapse formation. Dev Cell 2022 57(15) 1802-1816.e4  [ PubMed ID = 35809561 ] [ RRC reference ] Li Y, Zhang Y, Gan Q, Xu M, Ding X, Tang G, Liang J, Liu K, Liu X, Wang X, Guo L, Gao Z, Hao X, Yang C. C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death. Protein Cell 2018 9(12) 1013-1026  [ PubMed ID = 29611115 ] [ RRC reference ] Niwa S, Tao L, Lu SY, Liew GM, Feng W, Nachury MV, Shen K. BORC Regulates the Axonal Transport of Synaptic Vesicle Precursors by Activating ARL-8. Curr Biol 2017 27(17) 2569-2578.e4  [ PubMed ID = 28823680 ] [ RRC reference ] Fischer SE, Pan Q, Breen PC, Qi Y, Shi Z, Zhang C, Ruvkun G. Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans. Genes Dev 2013 27(24) 2678-95  [ PubMed ID = 24352423 ] [ RRC reference ] Wu YE, Huo L, Maeder CI, Feng W, Shen K. The balance between capture and dissociation of presynaptic proteins controls the spatial distribution of synapses. Neuron 2013 78(6) 994-1011  [ PubMed ID = 23727120 ] [ RRC reference ] Klassen MP, Wu YE, Maeder CI, Nakae I, Cueva JG, Lehrman EK, Tada M, Gengyo-Ando K, Wang GJ, Goodman M, Mitani S, Kontani K, Katada T, Shen K. An Arf-like small G protein, ARL-8, promotes the axonal transport of presynaptic cargoes by suppressing vesicle aggregation. Neuron 2010 66(5) 710-23  [ PubMed ID = 20547129 ] [ RRC reference ]