Home > 分離済み変異体 > tm2371

分離済み変異体

Allele Name		tm2371
Balance		Not Required
OutCross		Not Accepted
Sequence Name		C34D4.14
Gene Name		hecd-1
Worm Base	Allele Name	tm2371
	Gene Name	hecd-1
	Sequence	C34D4.14
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable. Dr. A. Dernburg: No defects in growth, fertility or meiotic chromosome behavior.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		25747/25748-26737/26738 (990 bp deletion)
Chromosome		IV
Putative gene structure		complement(join(20024..20131, 20187..20260, 20307..20574, 20629..20773, 20820..21242, 21300..21730, 21780..22723, 22806..23669, 23851..24187, 24255..24422, 24478..25920, 25968..26228, 26279..26392, 26508..26645, 26823..27206, 27285..27943, 27989..28179, 28238..28476, 28522..29013, 29083..29327, 29374..29731))
Map position		3.29
Balancer
Map position of balancer
Sequence of primers		IntFwd:TACCGAATGGTTGGCGAGTA,ExtFwd:TCTTCCATATCCACGCGAGT,IntRev:GCCAGGGAACACCTTATCGT,ExtRev:GACAGTATTGAGCCAGGGAA
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Ravanelli S, Li Q, Annibal A, Trifunovic A, Antebi A, Hoppe T. Reprograming of proteasomal degradation by branched chain amino acid metabolism. Aging Cell 2022 21(12) e13725  [ PubMed ID = 36168305 ] [ RRC reference ] Segref A, Vakkayil KL, Padvitski T, Li Q, Kroef V, Lormann J, Körner L, Finger F, Hoppe T. Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling. Nat Commun 2022 13(1) 5874  [ PubMed ID = 36198694 ] [ RRC reference ] Ackermann L, Schell M, Pokrzywa W, Kevei É, Gartner A, Schumacher B, Hoppe T. E4 ligase-specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis. Nat Struct Mol Biol 2016 23(11) 995-1002  [ PubMed ID = 27669035 ] [ RRC reference ] Segref A, Kevei É, Pokrzywa W, Schmeisser K, Mansfeld J, Livnat-Levanon N, Ensenauer R, Glickman MH, Ristow M, Hoppe T. Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system. Cell Metab 2014 19(4) 642-52  [ PubMed ID = 24703696 ] [ RRC reference ]