分離済み変異体

tm2366

Allele Nametm2366
BalanceNot Required
OutCrossNot Accepted
Sequence NameW06H3.1
Gene Nameimmt-2
Worm BaseAllele Name tm2366
Gene Name immt-2
Sequence W06H3.1
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" homozygous viable. Dr. A. van der Bliek: fertile, Sma (~20%), Gro, normal locomotion. Connected mitochondria in muscle.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 2406/2407-TC-3007/3008 (601 bp deletion + 2 bp insertion)
ChromosomeV
Putative gene structurejoin(2395..2418, 2465..2602, 2652..3527, 4280..4546, 4605..4699, 5061..5423, 5473..5701)
Map position11.17
Balancer
Map position of balancer
Sequence of primersExtFwd:CGTGACCGTGTACACGAAAG,IntFwd:CACGAAAGTACGTGACACGT,ExtRev:GCATGAGCCAAAATCGTGTG,IntRev:CCGCTACACGATCACTGTAG
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Wu X, Seida M, Abe T, Higashitani A.
Mitochonic acid 5 attenuates age-related neuromuscular dysfunction associated with mitochondrial Ca2+ overload in Caenorhabditis elegans.
NPJ Aging 2023 9(1) 20 
[ PubMed ID = 37528117 ] [ RRC reference ]

Head BP, Zulaika M, Ryazantsev S, van der Bliek AM.
A novel mitochondrial outer membrane protein, MOMA-1, that affects cristae morphology in Caenorhabditis elegans.
Mol Biol Cell 2011 22(6) 831-41 
[ PubMed ID = 21248201 ] [ RRC reference ]

Mun JY, Lee TH, Kim JH, Yoo BH, Bahk YY, Koo HS, Han SS.
Caenorhabditis elegans mitofilin homologs control the morphology of mitochondrial cristae and influence reproduction and physiology.
J Cell Physiol 2010 224(3) 748-56 
[ PubMed ID = 20578245 ] [ RRC reference ]