Home > 分離済み変異体 > tm2321

分離済み変異体

Allele Name		tm2321
Balance		Not Required
OutCross		Not Accepted
Sequence Name		R09E10.7
Gene Name		ebax-1
Worm Base	Allele Name	tm2321
	Gene Name	ebax-1
	Sequence	R09E10.7
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable. Dr. Y. Jin: sluggish movement, grows well.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		4554/4555-5105/5106 (551 bp deletion)
Chromosome		IV
Putative gene structure		join(2410..2469, 2518..2984, 3036..3335, 3380..4352, 4399..5612, 5660..5887, 5934..6819, 6871..7299, 7347..7492, 7539..7683, 7731..7859, 7908..8084)
Map position		4.57
Balancer
Map position of balancer
Sequence of primers		ExtFwd:CATGTGGTGGCATTGTCCAT,IntFwd:GAAACCATAGCCGACGCAAT,ExtRev:GGATAGATGTGCTCGGTGGT,IntRev:CGGTGGTTCGGTCCAGTATA
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Stubna MW, Shukla A, Bartel DP. Widespread destabilization of Caenorhabditis elegans microRNAs by the E3 ubiquitin ligase EBAX-1. RNA 2024 31(1) 51-66  [ PubMed ID = 39433399 ] [ RRC reference ] Nahar S, Morales Moya LJ, Brunner J, Hendriks GJ, Towbin B, Hauser YP, Brancati G, Gaidatzis D, Großhans H. Dynamics of miRNA accumulation during C. elegans larval development. Nucleic Acids Res 2024 52(9) 5336-5355  [ PubMed ID = 38381904 ] [ RRC reference ] Donnelly BF, Yang B, Grimme AL, Vieux KF, Liu CY, Zhou L, McJunkin K. The developmentally timed decay of an essential microRNA family is seed-sequence dependent. Cell Rep 2022 40(6) 111154  [ PubMed ID = 35947946 ] [ RRC reference ] Wang Z, Hou Y, Guo X, van der Voet M, Boxem M, Dixon JE, Chisholm AD, Jin Y. The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons. Neuron 2013 79(5) 903-16  [ PubMed ID = 24012004 ] [ RRC reference ]