Home > 分離済み変異体 > tm2313

分離済み変異体

Allele Name		tm2313
Balance		Not Required
OutCross		Not Accepted
Sequence Name		Y17G7B.15
Gene Name		cnt-1
Worm Base	Allele Name	tm2313
	Gene Name	cnt-1
	Sequence	Y17G7B.15
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable. Dr. K. Ashrai: normal fat content observed by Nile-Red staining. Dr. G. Hermann: wild-type gut granules. Dr. K. Matsumoto: SNB-1::GFP was not mislocalized in sensory neurons. Dr. H. Sawa: non-Psa.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		106366/106367-T-106710/106711 (344 bp deletion + 1 bp insertion)
Chromosome		II
Putative gene structure		complement(join(103510..103666, 103888..103998, 104841..105186, 106260..106841, 108452..108821, 110048..110179, 115377..115547, 117739..117828, 118711..118849, 119504..119680, 119819..119952, 119998..120069))
Map position		6.46
Balancer
Map position of balancer
Sequence of primers		ExtFwd:CCTCACCAGACCACGGATCA,IntFwd:CCACGGATCAGCATCTAATA,ExtRev:TCCACGACCGCATTCGAACA,IntRev:GTCCCAGGCAACGAAGTTTG
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Jiang HS, Han HF, Chen CY, Hsu KL, Kan HT, Lin WY, Wu MH, Tsai SY, Wu JC, Wu YC. Uridine 5'-monophosphate (UMP) synthesis connects nucleotide metabolism to programmed cell death in C. elegans. Cell Death Differ 2026 33(1) 25-37  [ PubMed ID = 40903566 ] [ RRC reference ] Wang Y, Arnold ML, Smart AJ, Wang G, Androwski RJ, Morera A, Nguyen KCQ, Schweinsberg PJ, Bai G, Cooper J, Hall DH, Driscoll M, Grant BD. Large vesicle extrusions from C. elegans neurons are consumed and stimulated by glial-like phagocytosis activity of the neighboring cell. Elife 2023 12   [ PubMed ID = 36861960 ] [ RRC reference ] Nakagawa A, Sullivan KD, Xue D. Caspase-activated phosphoinositide binding by CNT-1 promotes apoptosis by inhibiting the AKT pathway. Nat Struct Mol Biol 2014 21(12) 1082-90  [ PubMed ID = 25383666 ] [ RRC reference ] Shi A, Liu O, Koenig S, Banerjee R, Chen CC, Eimer S, Grant BD. RAB-10-GTPase-mediated regulation of endosomal phosphatidylinositol-4,5-bisphosphate. Proc Natl Acad Sci U S A 2012 109(35) E2306-15  [ PubMed ID = 22869721 ] [ RRC reference ]