Home > 分離済み変異体 > tm2252

分離済み変異体

Allele Name		tm2252
Balance		Not Required
OutCross		Not Accepted
Sequence Name		ZC477.5
Gene Name		rde-8
Worm Base	Allele Name	tm2252
	Gene Name	rde-8
	Sequence	ZC477.5
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable. Rde against gon-1 (RNAi).
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		16461/16462-GGTAGAGGTTATGGTGG-17665/17666 (1204 bp deletion + 17 bp insertion)
Chromosome		IV
Putative gene structure		complement(join(16318..16438, 16971..17053, 17098..17195, 17243..17671, 17720..17825, 17878..17977, 18024..18106))
Map position		3.29
Balancer
Map position of balancer
Sequence of primers		IntFwd:GGTTGTTGTGTAGAGTGGTC,ExtFwd:CTCAGGTGGCTGTGGTTGTT,IntRev:GATGAATGCGCCAGCAGTGT,ExtRev:CAGATGGACGTACTCACATC
Distributed lab
Depositor		Dr. S. Mitani
References		Please submit your publication Lowe DD, Shukla A, Kennedy SG. Viral RNA pUGylation promotes antiviral immunity in C. elegans. J Virol 2025 99(11) e0116925  [ PubMed ID = 41165327 ] [ RRC reference ] Lowe DD, Newman M, Ruvkun G, Kennedy SG. The microRNA miR-243 directs poly(UG) modification of a somatic mRNA in C. elegans. MicroPubl Biol 2025 2025   [ PubMed ID = 40880989 ] [ RRC reference ] Uebel CJ, Anderson DC, Mandarino LM, Manage KI, Aynaszyan S, Phillips CM. Distinct regions of the intrinsically disordered protein MUT-16 mediate assembly of a small RNA amplification complex and promote phase separation of Mutator foci. PLoS Genet 2018 14(7) e1007542  [ PubMed ID = 30036386 ] [ RRC reference ] Kim KW, Tang NH, Andrusiak MG, Wu Z, Chisholm AD, Jin Y. A Neuronal piRNA Pathway Inhibits Axon Regeneration in C. elegans. Neuron 2018 97(3) 511-519.e6  [ PubMed ID = 29395906 ] [ RRC reference ] Tsai HY, Chen CC, Conte D Jr, Moresco JJ, Chaves DA, Mitani S, Yates JR 3rd, Tsai MD, Mello CC. A ribonuclease coordinates siRNA amplification and mRNA cleavage during RNAi. Cell 2015 160(3) 407-19  [ PubMed ID = 25635455 ] [ RRC reference ]