分離済み変異体

tm2243

Allele Name

tm2243

Balance

Not Required

OutCross

Not Accepted

Sequence Name

F14F4.1

Gene Name

ntr-2

Worm Base

Allele Name

tm2243

Gene Name

ntr-2

Sequence

F14F4.1

Phenotype

homozygous viable. Dr. C. Bargmann: viable, fertile, normal thermotaxis. Dr. P. Sengupta: normal dye filling.

Mutation site

2875/2876-GTA-4015/4016 (1140 bp deletion + 3 bp insertion)

Chromosome

Putative gene structure

complement(join(2554..2687,2740..2901,2952..3047, 3095..3189, 3234..3318, 3403..3524, 3574..3701, 4982..5101, 6154..6228,6276..6455))

Map position

21.57

Balancer

Map position of balancer

Sequence of primers

ExtFwd:GACCGGTTACTGAAAGCGGT,IntFwd:TGAAAGCGGTGTAAGCATGA,ExtRev:TACCTGCAATCGCGCTCCAT,IntRev:GTGACCCTGATTTCGGTCAT

Distributed lab

Depositor

Dr. S. Mitani/NBRP

References

Please submit your publication

Chai CM, Park H, Sternberg PW.
Brain-wide bidirectional neuropeptide modulation of individual neuron classes regulates a developmental decision.
Curr Biol 2022 32(15) 3365-3373.e6
[ PubMed ID = 35679871 ] [ RRC reference ]

Scott E, Hudson A, Feist E, Calahorro F, Dillon J, de Freitas R, Wand M, Schoofs L, O'Connor V, Holden-Dye L.
An oxytocin-dependent social interaction between larvae and adult C. elegans.
Sci Rep 2017 7(1) 10122
[ PubMed ID = 28860630 ] [ RRC reference ]

Hapiak V, Summers P, Ortega A, Law WJ, Stein A, Komuniecki R.
Neuropeptides amplify and focus the monoaminergic inhibition of nociception in Caenorhabditis elegans.
J Neurosci 2013 33(35) 14107-16
[ PubMed ID = 23986246 ] [ RRC reference ]

Garrison JL, Macosko EZ, Bernstein S, Pokala N, Albrecht DR, Bargmann CI.
Oxytocin/vasopressin-related peptides have an ancient role in reproductive behavior.
Science 2012 338(6106) 540-3
[ PubMed ID = 23112335 ] [ RRC reference ]

Mills H, Wragg R, Hapiak V, Castelletto M, Zahratka J, Harris G, Summers P, Korchnak A, Law W, Bamber B, Komuniecki R.
Monoamines and neuropeptides interact to inhibit aversive behaviour in Caenorhabditis elegans.
EMBO J 2012 31(3) 667-78
[ PubMed ID = 22124329 ] [ RRC reference ]

Harris G, Mills H, Wragg R, Hapiak V, Castelletto M, Korchnak A, Komuniecki RW.
The monoaminergic modulation of sensory-mediated aversive responses in Caenorhabditis elegans requires glutamatergic/peptidergic cotransmission.
J Neurosci 2010 30(23) 7889-99
[ PubMed ID = 20534837 ] [ RRC reference ]