分離済み変異体

tm2227

Allele Nametm2227
BalanceNot Required
OutCrossNot Accepted
Sequence NameF41G3.4
Gene Namefis-1
Worm BaseAllele Name tm2227
Gene Name fis-1
Sequence F41G3.4
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" homozygous viable. Dr. D. Xue: Mol Cell 31, 586 (2008)
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 15682/15683-16316/16317 (634 bp deletion)
ChromosomeII
Putative gene structurejoin(15295..15345, 15387..15495, 15543..15622, 15808..15999)
Map position0.08
Balancer
Map position of balancer
Sequence of primersIntFwd:CTCCACCAACTAGGCTTATC,ExtFwd:CCAGGTAGCATTGCGTTAAG,IntRev:TAGAGCATGCGTTCAAGGTA,ExtRev:CCCGAGAGCCGGAGTGTTAT
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Traa A, Tamez González AA, Van Raamsdonk JM.
Developmental disruption of the mitochondrial fission gene drp-1 extends the longevity of daf-2 insulin/IGF-1 receptor mutant.
Geroscience 2025 47(1) 877-902 
[ PubMed ID = 39028454 ] [ RRC reference ]

Breckenridge DG, Kang BH, Kokel D, Mitani S, Staehelin LA, Xue D.
Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell-death execution pathways downstream of ced-3 and independent of ced-9.
Mol Cell 2008 31(4) 586-597 
[ PubMed ID = 18722182 ] [ RRC reference ]