Home > 分離済み変異体 > tm2223

分離済み変異体

Allele Name		tm2223
Allele Type		バランス済
Sequence Name		Y18D10A.5
Gene Name		gsk-3
Worm Base	Allele Name	tm2223
	Gene Name	gsk-3
	Sequence	Y18D10A.5
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		lethal or sterile. Dr. J. Kimble: most homozygotes are larval lethal with some sterile escapers. A low penetrance embryonic lethality has not been excluded. Dr. H. Sawa: not Psa.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		41421/41422-41811/41812 (390 bp deletion)
Chromosome		I
Putative gene structure		join(39072..39164, 40245..40513, 41360..41936, 44226..44375)
Map position		14.09
Balancer		,tmC27[tmIs1239]
Map position of balancer
Sequence of primers		IntRev:CGTCGGCGTATACTCGATAA,IntFwd:GCCCGGCACTATTCGAAGCA,ExtRev:CCGAGACGTCGGCGTATACT,ExtFwd:TGCAGAGTTGCCCGGCACTA
Distributed lab
Depositor		Dr. S. Mitani
References		Please submit your publication Chen X, Wang K, Mufti FUD, Xu D, Zhu C, Huang X, Zeng C, Jin Q, Huang X, Yan YH, Dong MQ, Feng X, Shi Y, Kennedy S, Guang S. Germ granule compartments coordinate specialized small RNA production. Nat Commun 2024 15(1) 5799  [ PubMed ID = 38987544 ] [ RRC reference ] Mazzetto M, Gonzalez LE, Sanchez N, Reinke V. Characterization of the distribution and dynamics of chromatin states in the C. elegans germline reveals substantial H3K4me3 remodeling during oogenesis. Genome Res 2024 34(1) 57-69  [ PubMed ID = 38164610 ] [ RRC reference ] de la Cova CC, Townley R, Greenwald I. Negative feedback by conserved kinases patterns the degradation of Caenorhabditiselegans Raf in vulval fate patterning. Development 2020 147(24)   [ PubMed ID = 33144396 ] [ RRC reference ] Furuta T, Joo HJ, Trimmer KA, Chen SY, Arur S. GSK-3 promotes S-phase entry and progression in C. elegans germline stem cells to maintain tissue output. Development 2018 145(10)   [ PubMed ID = 29695611 ] [ RRC reference ] Tanizawa Y, Kuhara A, Inada H, Kodama E, Mizuno T, Mori I. Inositol monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans. Genes Dev 2006 20(23) 3296-310  [ PubMed ID = 17158747 ] [ RRC reference ]