分離済み変異体

tm2114

Allele Nametm2114
BalanceNot Required
OutCrossNot Accepted
Sequence NameF56E3.3
Gene Nameklp-4
Worm BaseAllele Name tm2114
Gene Name klp-4
Sequence F56E3.3
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" homozygous viable. Dr. P. Sengupta: normal dye filling. Dr. C. Bargmann: locomotion OK, normal GFP::UNC-2 localization. Dr. O. Blacque: dye-filling normal. Dr. H. Sawa: 0% Psa.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 5626/5627-6373/6374 (747 bp deletion)
ChromosomeX
Putative gene structurecomplement(join(137..165, 250..388, 441..503, 552..625, 1505..1565, 1639..1806, 1849..2019, 2064..2237, 2286..2568, 2618..3270, 3319..3618, 3669..3852, 3903..4223, 4281..4495, 4569..4927, 4981..5080, 5129..5734, 5842..5908, 5980..6227, 6281..6368, 6422..6531, 6608..6842, 6899..6971, 7031..7097))
Map position-11.45
Balancer
Map position of balancer
Sequence of primersExtRev:GCTATTCGTGTACGCCCGTT,IntRev:GCCCGTTTAACAAAAGAGGT,ExtFwd:GACCTCGGAGGACAATACTA,IntFwd:GTCCAGAGTCTCTACTTGTC
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Heinze SD, Berger S, Engleitner S, Daube M, Hajnal A.
Prolonging somatic cell proliferation through constitutive hox gene expression in C. elegans.
Nat Commun 2023 14(1) 6850 
[ PubMed ID = 37891160 ] [ RRC reference ]

Magaletta ME, Perkins KJ, Deuchler CP, Pieczynski JN.
The Kinesin-3 motor, KLP-4, mediates axonal organization and cholinergic signaling in Caenorhabditis elegans.
FASEB Bioadv 2019 1(7) 450-460 
[ PubMed ID = 32123843 ] [ RRC reference ]

Moss BJ, Park L, Dahlberg CL, Juo P.
The CaM Kinase CMK-1 Mediates a Negative Feedback Mechanism Coupling the C. elegans Glutamate Receptor GLR-1 with Its Own Transcription.
PLoS Genet 2016 12(7) e1006180 
[ PubMed ID = 27462879 ] [ RRC reference ]

Monteiro MI, Ahlawat S, Kowalski JR, Malkin E, Koushika SP, Juo P.
The kinesin-3 family motor KLP-4 regulates anterograde trafficking of GLR-1 glutamate receptors in the ventral nerve cord of Caenorhabditis elegans.
Mol Biol Cell 2012 23(18) 3647-62 
[ PubMed ID = 22855524 ] [ RRC reference ]

Sugioka K, Mizumoto K, Sawa H.
Wnt regulates spindle asymmetry to generate asymmetric nuclear β-catenin in C. elegans.
Cell 2011 146(6) 942-54 
[ PubMed ID = 21925317 ] [ RRC reference ]