Home > 分離済み変異体 > tm2073

分離済み変異体

Allele Name		tm2073
Balance		Not Required
OutCross		Not Accepted
Sequence Name		F10G8.7
Gene Name		ercc-1
Worm Base	Allele Name	tm2073
	Gene Name	ercc-1
	Sequence	F10G8.7
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		23987/23988-24789/24790 (802 bp deletion)
Chromosome		I
Putative gene structure		join(11802..11856, 23527..23756, 24439..24510, 24587..24688, 25639..25703, 27191..27310, 27642..27786)
Map position		4.58
Balancer
Map position of balancer
Sequence of primers		ExtRev:CCCTGGCGTAGACCTAAATA,IntRev:CGGTAGGAATTACTCTGTTC,ExtFwd:CCTTCGTGAATCAGTGAGCT,IntFwd:TACCGTATTTTTGAGCGCGA
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Wilson DM 3rd, Rieckher M, Williams AB, Schumacher B. Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans. Nucleic Acids Res 2017 45(16) 9467-9480  [ PubMed ID = 28934497 ] [ RRC reference ] Jablonski AM, Lamitina T, Liachko NF, Sabatella M, Lu J, Zhang L, Ostrow LW, Gupta P, Wu CY, Doshi S, Mojsilovic-Petrovic J, Lans H, Wang J, Kraemer B, Kalb RG. Loss of RAD-23 Protects Against Models of Motor Neuron Disease by Enhancing Mutant Protein Clearance. J Neurosci 2015 35(42) 14286-306  [ PubMed ID = 26490867 ] [ RRC reference ] van Schendel R, Roerink SF, Portegijs V, van den Heuvel S, Tijsterman M. Polymerase Θ is a key driver of genome evolution and of CRISPR/Cas9-mediated mutagenesis. Nat Commun 2015 6 7394  [ PubMed ID = 26077599 ] [ RRC reference ] Lans H, Lindvall JM, Thijssen K, Karambelas AE, Cupac D, Fensgård O, Jansen G, Hoeijmakers JH, Nilsen H, Vermeulen W. DNA damage leads to progressive replicative decline but extends the life span of long-lived mutant animals. Cell Death Differ 2013 20(12) 1709-18  [ PubMed ID = 24013725 ] [ RRC reference ] Lans H, Vermeulen W. Nucleotide Excision Repair in Caenorhabditis elegans. Mol Biol Int 2011 2011 542795  [ PubMed ID = 22091407 ] [ RRC reference ] Lans H, Marteijn JA, Schumacher B, Hoeijmakers JH, Jansen G, Vermeulen W. Involvement of global genome repair, transcription coupled repair, and chromatin remodeling in UV DNA damage response changes during development. PLoS Genet 2010 6(5) e1000941  [ PubMed ID = 20463888 ] [ RRC reference ] Pontier DB, Tijsterman M. A robust network of double-strand break repair pathways governs genome integrity during C. elegans development. Curr Biol 2009 19(16) 1384-8  [ PubMed ID = 19646877 ] [ RRC reference ]