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分離済み変異体

Allele Name		tm2058
Balance		Not Required
OutCross		Not Accepted
Sequence Name		Y47D3A.25
Gene Name		rab-35
Worm Base	Allele Name	tm2058
	Gene Name	rab-35
	Sequence	Y47D3A.25
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable. Dr. Y. Jin: normal motor and touch axons and synapses, grows well. Dr. S. Eimer: does not affect levamisole receptor trafficking.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		175060/175061-AA-175540/175541 (380 bp deletion + 2 bp insertion)
Chromosome		III
Putative gene structure		complement(join(170727..170873, 172420..172544, 173752..173876, 174390..174513, 175288..175396))
Map position		8.45
Balancer
Map position of balancer
Sequence of primers		IntRev:CGGTTCCAAAAGCCGCTAAG,ExtRev:TCGCCCCTAAAACTGCACTG,IntFwd:CGTGTGTTCCGCGGTAGTAA,ExtFwd:GACAACGACTCCGTGTGTTC
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Bae EJ, Kim DK, Kim C, Mante M, Adame A, Rockenstein E, Ulusoy A, Klinkenberg M, Jeong GR, Bae JR, Lee C, Lee HJ, Lee BD, Di Monte DA, Masliah E, Lee SJ. LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation. Nat Commun 2018 9(1) 3465  [ PubMed ID = 30150626 ] [ RRC reference ] Haley R, Wang Y, Zhou Z. The small GTPase RAB-35 defines a third pathway that is required for the recognition and degradation of apoptotic cells. PLoS Genet 2018 14(8) e1007558  [ PubMed ID = 30138370 ] [ RRC reference ] Sasidharan N, Sumakovic M, Hannemann M, Hegermann J, Liewald JF, Olendrowitz C, Koenig S, Grant BD, Rizzoli SO, Gottschalk A, Eimer S. RAB-5 and RAB-10 cooperate to regulate neuropeptide release in Caenorhabditis elegans. Proc Natl Acad Sci U S A 2012 109(46) 18944-9  [ PubMed ID = 23100538 ] [ RRC reference ]