Home > 分離済み変異体 > tm2031

分離済み変異体

Allele Name		tm2031
Balance		Not Required
OutCross		Not Accepted
Sequence Name		K02G10.6b
Gene Name		hyl-2
Worm Base	Allele Name	tm2031
	Gene Name	hyl-2
	Sequence	K02G10.6b
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		24518/24519-26120/26121 (1602 bp deletion)
Chromosome		X
Putative gene structure		complement(join(23841..23957, 24344..24611, 24658..24810, 24857..24994, 25646..25733, 25780..25861, 25911..26054))
Map position		-6.9
Balancer
Map position of balancer
Sequence of primers		IntRev:CACTGCTCTACTGATAACAC,IntFwd:CCGTTAACAGAAGCATGATG,ExtRev:AGGCAGAACTGCCGTCGTTC,ExtFwd:ATACGCATTGGTGACAGGTA
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Watzinger G, Bennett HL. Ceramide Synthase HYL-2 is Required for Neural Preconditioning to Anoxia in Caenorhabditis elegans . MicroPubl Biol 2024 2024   [ PubMed ID = 38872843 ] [ RRC reference ] Chan JP, Brown J, Hark B, Nolan A, Servello D, Hrobuchak H, Staab TA. Loss of Sphingosine Kinase Alters Life History Traits and Locomotor Function in Caenorhabditis elegans. Front Genet 2017 8 132  [ PubMed ID = 28983319 ] [ RRC reference ] Ladage ML, King SD, Burks DJ, Quan DL, Garcia AM, Azad RK, Padilla PA. Glucose or Altered Ceramide Biosynthesis Mediate Oxygen Deprivation Sensitivity Through Novel Pathways Revealed by Transcriptome Analysis in Caenorhabditis elegans. G3 (Bethesda) 2016 6(10) 3149-3160  [ PubMed ID = 27507791 ] [ RRC reference ] Garcia AM, Ladage ML, Dumesnil DR, Zaman K, Shulaev V, Azad RK, Padilla PA. Glucose induces sensitivity to oxygen deprivation and modulates insulin/IGF-1 signaling and lipid biosynthesis in Caenorhabditis elegans. Genetics 2015 200(1) 167-84  [ PubMed ID = 25762526 ] [ RRC reference ] Mosbech MB, Kruse R, Harvald EB, Olsen AS, Gallego SF, Hannibal-Bach HK, Ejsing CS, Færgeman NJ. Functional loss of two ceramide synthases elicits autophagy-dependent lifespan extension in C. elegans. PLoS One 2013 8(7) e70087  [ PubMed ID = 23894595 ] [ RRC reference ] Menuz V, Howell KS, Gentina S, Epstein S, Riezman I, Fornallaz-Mulhauser M, Hengartner MO, Gomez M, Riezman H, Martinou JC. Protection of C. elegans from anoxia by HYL-2 ceramide synthase. Science 2009 324(5925) 381-4  [ PubMed ID = 19372430 ] [ RRC reference ]