Home > 分離済み変異体 > tm1981

分離済み変異体

Allele Name		tm1981
Allele Type		通常株
Sequence Name		F10G8.7
Gene Name		ercc-1
Worm Base	Allele Name	tm1981
	Gene Name	ercc-1
	Sequence	F10G8.7
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		24319/24320-24938/24939 (619 bp deletion)
Chromosome		I
Putative gene structure		join(11802..11856, 23527..23756, 24439..24510, 24587..24688, 25639..25703, 27191..27310, 27642..27786)
Map position		4.58
Balancer
Map position of balancer
Sequence of primers		ExtFwd:CCTTCGTGAATCAGTGAGCT,IntFwd:TACCGTATTTTTGAGCGCGA,ExtRev:CCCTGGCGTAGACCTAAATA,IntRev:CGGTAGGAATTACTCTGTTC
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Yan J, Bhanshali F, Shuzenji C, Mendenhall TT, Taylor SKB, Ermakova G, Cheng X, Bai P, Diwan G, Seraj D, Meyer JN, Sorensen PH, Hartman JH, Taubert S. Eukaryotic Elongation Factor 2 Kinase EFK-1/eEF2K promotes starvation resistance by preventing oxidative damage in C. elegans. Nat Commun 2025 16(1) 1752  [ PubMed ID = 39966347 ] [ RRC reference ] Rieckher M, Gallrein C, Alquezar-Artieda N, Bourached-Silva N, Vaddavalli PL, Mares D, Backhaus M, Blindauer T, Greger K, Wiesner E, Pontel LB, Schumacher B. Distinct DNA repair mechanisms prevent formaldehyde toxicity during development, reproduction and aging. Nucleic Acids Res 2024 52(14) 8271-8285  [ PubMed ID = 38894680 ] [ RRC reference ] Ye FB, Hamza A, Singh T, Flibotte S, Hieter P, O'Neil NJ. A Multimodal Genotoxic Anticancer Drug Characterized by Pharmacogenetic Analysis in Caenorhabditis elegans. Genetics 2020 215(3) 609-621  [ PubMed ID = 32414869 ] [ RRC reference ] Rossillo M, Ringstad N. Development of specialized sensory neurons engages a nuclear receptor required for functional plasticity. Genes Dev 2020 34(23-24) 1666-1679  [ PubMed ID = 33184226 ] [ RRC reference ] Gurkar AU, Robinson AR, Cui Y, Li X, Allani SK, Webster A, Muravia M, Fallahi M, Weissbach H, Robbins PD, Wang Y, Kelley EE, Croix CMS, Niedernhofer LJ, Gill MS. Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging. Redox Biol 2018 18 191-199  [ PubMed ID = 30031267 ] [ RRC reference ] Wilson DM 3rd, Rieckher M, Williams AB, Schumacher B. Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans. Nucleic Acids Res 2017 45(16) 9467-9480  [ PubMed ID = 28934497 ] [ RRC reference ] Lans H, Vermeulen W. Nucleotide Excision Repair in Caenorhabditis elegans. Mol Biol Int 2011 2011 542795  [ PubMed ID = 22091407 ] [ RRC reference ] Agostinho A, Meier B, Sonneville R, Jagut M, Woglar A, Blow J, Jantsch V, Gartner A. Combinatorial regulation of meiotic holliday junction resolution in C. elegans by HIM-6 (BLM) helicase, SLX-4, and the SLX-1, MUS-81 and XPF-1 nucleases. PLoS Genet 2013 9(7) e1003591  [ PubMed ID = 23901331 ] [ RRC reference ] Greer EL, Blanco MA, Gu L, Sendinc E, Liu J, Aristizábal-Corrales D, Hsu CH, Aravind L, He C, Shi Y. DNA Methylation on N6-Adenine in C. elegans. Cell 2015 161(4) 868-78  [ PubMed ID = 25936839 ] [ RRC reference ]