分離済み変異体

tm1962

Allele Name

tm1962

Allele Type

通常株

Sequence Name

F14F3.2

Gene Name

git-1

Worm Base

Allele Name

tm1962

Gene Name

git-1

Sequence

F14F3.2

Phenotype

homozygous viable. Dr. M. Leroux: Dyf normal. Dr. Y. Jin: no specific neuronal phenotype is found. Dr. K. Shen: no apparent synaptic phenotype in HSNL, DA9, AVE and AFD as determined by examining GFP::RAB-3 or VAMP::YFP. Dr. H. Sawa: non-Psa.

Mutation site

31052/31053-GAAACCCATTCAAGCTATAAATA-31535/31536 (483 bp deletion + 23 bp insertion)

Chromosome

Putative gene structure

join(29657..29681, 29728..29847, 29995..30076, 30132..30203, 30260..30412, 30481..30664, 30711..31016, 31061..31257, 31301..31501, 31551..31733, 32006..32184, 32233..32348, 32398..32484, 32793..32900)

Map position

2.23

Balancer

Map position of balancer

Sequence of primers

ExtFwd:AGCAGAGGCGCTTGACCGTA,IntFwd:AAGTCGAATGGGCGTCGGTA,ExtRev:TTCCCACTGGTGGCATAACT,IntRev:TAGCCAATGGAGATGGCATC

Distributed lab

Depositor

Dr. S. Mitani/NBRP

References

Please submit your publication

Yuval O, Iosilevskii Y, Meledin A, Podbilewicz B, Shemesh T.
Neuron tracing and quantitative analyses of dendritic architecture reveal symmetrical three-way-junctions and phenotypes of git-1 in C. elegans.
PLoS Comput Biol 2021 17(7) e1009185
[ PubMed ID = 34280180 ] [ RRC reference ]

Suman SK, Daday C, Ferraro T, Vuong-Brender T, Tak S, Quintin S, Robin F, Gräter F, Labouesse M.
The plakin domain of C. elegans VAB-10/plectin acts as a hub in a mechanotransduction pathway to promote morphogenesis.
Development 2019 146(24)
[ PubMed ID = 31784459 ] [ RRC reference ]

Lardennois A, Pásti G, Ferraro T, Llense F, Mahou P, Pontabry J, Rodriguez D, Kim S, Ono S, Beaurepaire E, Gally C, Labouesse M.
An actin-based viscoplastic lock ensures progressive body-axis elongation.
Nature 2019 573(7773) 266-270
[ PubMed ID = 31462781 ] [ RRC reference ]

Zhang H, Landmann F, Zahreddine H, Rodriguez D, Koch M, Labouesse M.
A tension-induced mechanotransduction pathway promotes epithelial morphogenesis.
Nature 2011 471(7336) 99-103
[ PubMed ID = 21368832 ] [ RRC reference ]

Peters EC, Gossett AJ, Goldstein B, Der CJ, Reiner DJ.
Redundant canonical and noncanonical Caenorhabditis elegans p21-activated kinase signaling governs distal tip cell migrations.
G3 (Bethesda) 2013 3(2) 181-95
[ PubMed ID = 23390595 ] [ RRC reference ]

Zhang Y, Li W, Li L, Li Y, Fu R, Zhu Y, Li J, Zhou Y, Xiong S, Zhang H.
Structural damage in the C. elegans epidermis causes release of STA-2 and induction of an innate immune response.
Immunity 2015 42(2) 309-320
[ PubMed ID = 25692704 ] [ RRC reference ]

Morrissey MA, Keeley DP, Hagedorn EJ, McClatchey STH, Chi Q, Hall DH, Sherwood DR.
B-LINK: a hemicentin, plakin, and integrin-dependent adhesion system that links tissues by connecting adjacent basement membranes.
Dev Cell 2014 31(3) 319-331
[ PubMed ID = 25443298 ] [ RRC reference ]

Lucanic M, Cheng HJ.
A RAC/CDC-42-independent GIT/PIX/PAK signaling pathway mediates cell migration in C. elegans.
PLoS Genet 2008 4(11) e1000269
[ PubMed ID = 19023419 ] [ RRC reference ]

Patel MR, Lehrman EK, Poon VY, Crump JG, Zhen M, Bargmann CI, Shen K.
Hierarchical assembly of presynaptic components in defined C. elegans synapses.
Nat Neurosci 2006 9(12) 1488-98
[ PubMed ID = 17115039 ] [ RRC reference ]