分離済み変異体

tm1908

Allele Nametm1908
BalanceNot Required
OutCrossNot Accepted
Sequence NameT24D8.5
Gene Namenlp-2
Worm BaseAllele Name tm1908
Gene Name nlp-2
Sequence T24D8.5
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" homozygous viable. Dr. C. Kenyon: grossly normal morphology and fertility, does not form dauer at 25C.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 5714/5715-TT-6656/6657 (942 bp deletion + 2 bp insertion)
ChromosomeX
Putative gene structurecomplement(join(5918..6161, 6216..6397, 6455..6544))
Map position-15.63
Balancer
Map position of balancer
Sequence of primersIntFwd:AATCGGACCCATACGTGCCT,ExtRev:CTACGGATACTTCAAGTGGT,ExtFwd:CGAACCGGCATACATTTAGT,IntRev:TGACCCGGCTCCTAATACTA
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Aviles S, Subramanian S, Nelson MD.
New alleles of nlp-2 , nlp-22 , and nlp-23 demonstrate that they are dispensable for stress-induced sleep in C. elegans.
MicroPubl Biol 2024 2024  
[ PubMed ID = 38371321 ] [ RRC reference ]

Van der Auwera P, Frooninckx L, Buscemi K, Vance RT, Watteyne J, Mirabeau O, Temmerman L, De Haes W, Fancsalszky L, Gottschalk A, Raizen DM, Nelson MD, Schoofs L, Beets I.
RPamide neuropeptides NLP-22 and NLP-2 act through GnRH-like receptors to promote sleep and wakefulness in C. elegans.
Sci Rep 2020 10(1) 9929 
[ PubMed ID = 32555288 ] [ RRC reference ]

Yemini E, Jucikas T, Grundy LJ, Brown AE, Schafer WR.
A database of Caenorhabditis elegans behavioral phenotypes.
Nat Methods 2013 10(9) 877-9 
[ PubMed ID = 23852451 ] [ RRC reference ]