Home > 分離済み変異体 > tm1905

分離済み変異体

Allele Name		tm1905
Allele Type		通常株
Sequence Name		Y17G7B.2
Gene Name		ash-2
Worm Base	Allele Name	tm1905
	Gene Name	ash-2
	Sequence	Y17G7B.2
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		lethal or sterile. Dr. H.C. Korswagen: lin-22-like multiple postdeirid phenotypes. Dr. O. Hobert: does not affect ASE development.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		11628/11629-12229/12230 (601 bp deletion)
Chromosome		II
Putative gene structure		join(11683..11753, 11836..11928, 11980..12304, 13242..13462, 14218..14331, 15865..16127, 17187..17299, 18228..18428, 18624..18714, 19438..19658)
Map position		5.54
Balancer
Map position of balancer
Sequence of primers		ExtFwd:TTCGACGGCGAGGCGATTGT,IntFwd:GTCGCGGTCGATAAGCACTC,ExtRev:CGTGGCTCACGGTTTTCCCT,IntRev:CTGCCTCGTGTAGTGGTCCT
Distributed lab
Depositor		Dr. S. Mitani
References		Please submit your publication Abay-Nørgaard S, Attianese B, Boreggio L, Salcini AE. Regulators of H3K4 methylation mutated in neurodevelopmental disorders control axon guidance in Caenorhabditis elegans. Development 2020 147(15)   [ PubMed ID = 32675280 ] [ RRC reference ] Nono M, Kishimoto S, Sato-Carlton A, Carlton PM, Nishida E, Uno M. Intestine-to-Germline Transmission of Epigenetic Information Intergenerationally Ensures Systemic Stress Resistance in C. elegans. Cell Rep 2020 30(10) 3207-3217.e4  [ PubMed ID = 32160530 ] [ RRC reference ] Xiao Y, Bedet C, Robert VJ, Simonet T, Dunkelbarger S, Rakotomalala C, Soete G, Korswagen HC, Strome S, Palladino F. Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells. Proc Natl Acad Sci U S A 2011 108(20) 8305-10  [ PubMed ID = 21527717 ] [ RRC reference ] Wang S, Fisher K, Poulin GB. Lineage specific trimethylation of H3 on lysine 4 during C. elegans early embryogenesis. Dev Biol 2011 355(2) 227-38  [ PubMed ID = 21549110 ] [ RRC reference ] Poole RJ, Bashllari E, Cochella L, Flowers EB, Hobert O. A Genome-Wide RNAi Screen for Factors Involved in Neuronal Specification in Caenorhabditis elegans. PLoS Genet 2011 7(6) e1002109  [ PubMed ID = 21698137 ] [ RRC reference ] Zuryn S, Ahier A, Portoso M, White ER, Morin MC, Margueron R, Jarriault S. Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation. Science 2014 345(6198) 826-9  [ PubMed ID = 25124442 ] [ RRC reference ] Robert VJ, Mercier MG, Bedet C, Janczarski S, Merlet J, Garvis S, Ciosk R, Palladino F. The SET-2/SET1 histone H3K4 methyltransferase maintains pluripotency in the Caenorhabditis elegans germline. Cell Rep 2014 9(2) 443-50  [ PubMed ID = 25310986 ] [ RRC reference ]