分離済み変異体

tm1877

Allele Nametm1877
BalanceCompleted
OutCrossNot Accepted
Sequence NameF57H12.1
Gene Namearf-3
Worm BaseAllele Name tm1877 (x1)
Gene Name arf-3
Sequence F57H12.1
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" lethal or sterile. Dr. G. Garriga: larval lethal. no obvious AVM/PVM phenotype in wild-type or sensitized mutant backgrounds.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 14861/14862-15492/15493 (631 bp deletion)
ChromosomeIV
Putative gene structurejoin(15178..15228, 15279..15375, 15503..15627, 15676..15858, 16021..16107)
Map position3.54
BalancernT1
Map position of balancer
Sequence of primersExtFwd:GGACGCAATGCAGCTAAAAC,ExtRev:CGAGCAAGCCATTGTGGTGA,IntRev:ACTGTTGCGATGAAGTGGAC,IntFwd:CACTTGGTGGAGCGAATGTC
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Zhai J, Zhang L, Mojsilovic-Petrovic J, Jian X, Thomas J, Homma K, Schmitz A, Famulok M, Ichijo H, Argon Y, Randazzo PA, Kalb RG.
Inhibition of Cytohesins Protects against Genetic Models of Motor Neuron Disease.
J Neurosci 2015 35(24) 9088-105 
[ PubMed ID = 26085633 ] [ RRC reference ]

Skorobogata O, Escobar-Restrepo JM, Rocheleau CE.
An AGEF-1/Arf GTPase/AP-1 ensemble antagonizes LET-23 EGFR basolateral localization and signaling during C. elegans vulva induction.
PLoS Genet 2014 10(10) e1004728 
[ PubMed ID = 25329472 ] [ RRC reference ]

Teuliere J, Cordes S, Singhvi A, Talavera K, Garriga G.
Asymmetric neuroblast divisions producing apoptotic cells require the cytohesin GRP-1 in Caenorhabditis elegans.
Genetics 2014 198(1) 229-47 
[ PubMed ID = 25053664 ] [ RRC reference ]