Home > 分離済み変異体 > tm1802

分離済み変異体

Allele Name		tm1802
Balance		Completed
OutCross		Not Accepted
Sequence Name		R53.3
Gene Name		egl-43
Worm Base	Allele Name	tm1802 (x1)
	Gene Name	egl-43
	Sequence	R53.3
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		lethal or sterile. Dr. P.W. Sternberg: Development 134, 669 (2007). Dr.A. Hajnal: Dev. Biol. 308, 187 (2007).
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		18540/18541-ACT-19077/19078 (537 bp deletion + 3 bp insertion)
Chromosome		II
Putative gene structure		join(12631..12750, 14458..14559, 14615..14745, 16034..16195, 17196..17310, 17746..17931, 18385..18482, 18633..19137, 19275..19346, 19459..19599)
Map position		1.82
Balancer		,mnC1 [dpy-10(e128) unc52(e444) nIs190 let-?]
Map position of balancer
Sequence of primers		ExtFwd:CGTGCAATGCTCCTGGGCTA,IntRev:TGCGGGGGGTTACTGTAGCA,ExtRev:TTGTGGGGTGTCAGCGAGGT,IntFwd:ACCCCATAATCTCACAACAG
Distributed lab
Depositor		Dr. S. Mitani
References		Please submit your publication Deng T, Stempor P, Appert A, Daube M, Ahringer J, Hajnal A, Lattmann E. The Caenorhabditis elegans homolog of the Evi1 proto-oncogene, egl-43, coordinates G1 cell cycle arrest with pro-invasive gene expression during anchor cell invasion. PLoS Genet 2020 16(3) e1008470  [ PubMed ID = 32203506 ] [ RRC reference ] Medwig-Kinney TN, Smith JJ, Palmisano NJ, Tank S, Zhang W, Matus DQ. A developmental gene regulatory network for C. elegans anchor cell invasion. Development 2020 147(1)   [ PubMed ID = 31806663 ] [ RRC reference ] Rimann I, Hajnal A. Regulation of anchor cell invasion and uterine cell fates by the egl-43 Evi-1 proto-oncogene in Caenorhabditis elegans. Dev Biol 2007 308(1) 187-95  [ PubMed ID = 17573066 ] [ RRC reference ] Hwang BJ, Meruelo AD, Sternberg PW. C. elegans EVI1 proto-oncogene, EGL-43, is necessary for Notch-mediated cell fate specification and regulates cell invasion. Development 2007 134(4) 669-79  [ PubMed ID = 17215301 ] [ RRC reference ]