Home > 分離済み変異体 > tm1689

分離済み変異体

Allele Name		tm1689
Balance		Not Required
OutCross		Not Accepted
Sequence Name		F28F8.6
Gene Name		atx-3
Worm Base	Allele Name	tm1689
	Gene Name	atx-3
	Sequence	F28F8.6
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable. Dr. P. Maciel: FASEB J. 21, 1126 (2007).
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		28875/28876-GAAAAA-29535/29536 (660 bp deletion + 6 bp insertion)
Chromosome		V
Putative gene structure		complement(join(28399..28883, 29029..29183, 29234..29379, 29428..29595))
Map position		8.39
Balancer
Map position of balancer
Sequence of primers		IntFwd:GCACTAGCTTAAGCTCGAAT,ExtFwd:CTACTCCTCGTGGAGCACTA,ExtRev:GGAGACTTGAAGTCGCCGAA,IntRev:GCGGTGTCGTTATTTCGGAG
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Herzog LK, Kevei É, Marchante R, Böttcher C, Bindesbøll C, Lystad AH, Pfeiffer A, Gierisch ME, Salomons FA, Simonsen A, Hoppe T, Dantuma NP. The Machado-Joseph disease deubiquitylase ataxin-3 interacts with LC3C/GABARAP and promotes autophagy. Aging Cell 2020 19(1) e13051  [ PubMed ID = 31625269 ] [ RRC reference ] Fardghassemi Y, Tauffenberger A, Gosselin S, Parker JA. Rescue of ATXN3 neuronal toxicity in Caenorhabditiselegans by chemical modification of endoplasmic reticulum stress. Dis Model Mech 2017 10(12) 1465-1480  [ PubMed ID = 29061563 ] [ RRC reference ] Rodrigues AJ, Coppola G, Santos C, Costa Mdo C, Ailion M, Sequeiros J, Geschwind DH, Maciel P. Functional genomics and biochemical characterization of the C. elegans orthologue of the Machado-Joseph disease protein ataxin-3. FASEB J 2007 21(4) 1126-36  [ PubMed ID = 17234717 ] [ RRC reference ]