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分離済み変異体

Allele Name		tm1682
Balance		Not Required
OutCross		Not Accepted
Sequence Name		F57B10.6
Gene Name		xpg-1
Worm Base	Allele Name	tm1682
	Gene Name	xpg-1
	Sequence	F57B10.6
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable. Dr. M. Driscoll: no effect on necrotic cell death. Dr. W. Vermeulen: normal locomotion but UV sensitive. Dr. S. Boulton: not Him, does not genetically interact with him-9 or him-6.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		9992/9993-10871/10872 (879 bp deletion)
Chromosome		I
Putative gene structure		join(10316..10403, 10538..10803, 11239..11565, 11621..11704, 11962..12397, 12445..12918, 12969..13129, 13176..13307, 13394..13915)
Map position		1.21
Balancer
Map position of balancer
Sequence of primers		ExtRev:TCTGGTCCAGTTACGTTGAT,IntFwd:ACGGAGATCAATTTGCATCC,IntRev:GAGTATCCACCTGTGGAGGT,ExtFwd:GGTTGGACAAATGGCGTTAT
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Yan J, Bhanshali F, Shuzenji C, Mendenhall TT, Taylor SKB, Ermakova G, Cheng X, Bai P, Diwan G, Seraj D, Meyer JN, Sorensen PH, Hartman JH, Taubert S. Eukaryotic Elongation Factor 2 Kinase EFK-1/eEF2K promotes starvation resistance by preventing oxidative damage in C. elegans. Nat Commun 2025 16(1) 1752  [ PubMed ID = 39966347 ] [ RRC reference ] Muniesa-Vargas A, Davó-Martínez C, Ribeiro-Silva C, van der Woude M, Thijssen KL, Haspels B, Häckes D, Kaynak ÜU, Kanaar R, Marteijn JA, Theil AF, Kuijten MMP, Vermeulen W, Lans H. Persistent TFIIH binding to non-excised DNA damage causes cell and developmental failure. Nat Commun 2024 15(1) 3490  [ PubMed ID = 38664429 ] [ RRC reference ] Lans H, Lindvall JM, Thijssen K, Karambelas AE, Cupac D, Fensgård O, Jansen G, Hoeijmakers JH, Nilsen H, Vermeulen W. DNA damage leads to progressive replicative decline but extends the life span of long-lived mutant animals. Cell Death Differ 2013 20(12) 1709-18  [ PubMed ID = 24013725 ] [ RRC reference ] Stergiou L, Eberhard R, Doukoumetzidis K, Hengartner MO. NER and HR pathways act sequentially to promote UV-C-induced germ cell apoptosis in Caenorhabditis elegans. Cell Death Differ 2011 18(5) 897-906  [ PubMed ID = 21151025 ] [ RRC reference ] Lans H, Vermeulen W. Nucleotide Excision Repair in Caenorhabditis elegans. Mol Biol Int 2011 2011 542795  [ PubMed ID = 22091407 ] [ RRC reference ]