分離済み変異体

tm1579

Allele Name

tm1579

Balance

Not Required

OutCross

Not Accepted

Sequence Name

F32A11.2

Gene Name

hpr-17

Worm Base

Allele Name

tm1579

Gene Name

hpr-17

Sequence

F32A11.2

Phenotype

homozygous viable. Dr. M. Hengartner: sensitive to ionizing radiation and defective in the cell cycle arrest response and the induction of apoptosis.

Mutation site

25612/25613-26350/26351 (738 bp deletion)

Chromosome

Putative gene structure

complement(join(23377..23662, 23719..23842, 23889..24075, 25192..25617, 26240..26589, 26641..26722, 26774..26863))

Map position

14.59

Balancer

Map position of balancer

Sequence of primers

ExtFwd:TTCGAACGGGCTGCGACACA,IntFwd:CTCAGAAGTCATACTCGACA,ExtRev:CTGCGTCCGCCATTTATCTG,IntRev:CGGTGCAGGTCACCGATAGT

Distributed lab

Depositor

Dr. S. Mitani/NBRP

References

Please submit your publication

Bailly AP, Perrin A, Serrano-Macia M, Maghames C, Leidecker O, Trauchessec H, Martinez-Chantar ML, Gartner A, Xirodimas DP.
The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity.
Cell Rep 2019 29(1) 212-224.e8
[ PubMed ID = 31577950 ] [ RRC reference ]

Cheng C, Shtessel L, Brady MM, Ahmed S.
Caenorhabditis elegans POT-2 telomere protein represses a mode of alternative lengthening of telomeres with normal telomere lengths.
Proc Natl Acad Sci U S A 2012 109(20) 7805-10
[ PubMed ID = 22547822 ] [ RRC reference ]

Bailly AP, Freeman A, Hall J, Déclais AC, Alpi A, Lilley DM, Ahmed S, Gartner A.
The Caenorhabditis elegans homolog of Gen1/Yen1 resolvases links DNA damage signaling to DNA double-strand break repair.
PLoS Genet 2010 6(7) e1001025
[ PubMed ID = 20661466 ] [ RRC reference ]

Boerckel J, Walker D, Ahmed S.
The Caenorhabditis elegans Rad17 homolog HPR-17 is required for telomere replication.
Genetics 2007 176(1) 703-9
[ PubMed ID = 17339221 ] [ RRC reference ]