分離済み変異体

tm1353

Allele Nametm1353
BalanceNot Required
OutCrossNot Accepted
Sequence NameF30A10.1
Gene Namecalm-1
Worm BaseAllele Name tm1353
Gene Name calm-1
Sequence F30A10.1
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" homozygous viable. Dr. M. Driscoll: normal in regard to growth, locomotion, brood size. Dr. Y. Jin: no specific phenotype is found.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 2582/2583-3200/3201 (618 bp deletion)
ChromosomeI
Putative gene structurecomplement(join(818..1035, 1330..1477, 2053..2205, 2814..2913, 2974..3290))
Map position3.77
Balancer
Map position of balancer
Sequence of primersIntRev:ATCAACCTAATTTGCCGTGC,ExtRev:CATGCGGAATGAAACACGCT,IntFwd:TTGATAGCCACGGTAGGATT,ExtFwd:CGCACATTCATTTGCGCGTG
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Zou W, Fan Y, Liu J, Cheng H, Hong H, Al-Sheikh U, Li S, Zhu L, Li R, He L, Tang YQ, Zhao G, Zhang Y, Wang F, Zhan R, Zheng X, Kang L.
Anoctamin-1 is a core component of a mechanosensory anion channel complex in C. elegans.
Nat Commun 2025 16(1) 1680 
[ PubMed ID = 39956854 ] [ RRC reference ]

Tang YQ, Lee SA, Rahman M, Vanapalli SA, Lu H, Schafer WR.
Ankyrin Is An Intracellular Tether for TMC Mechanotransduction Channels.
Neuron 2020 107(1) 112-125.e10 
[ PubMed ID = 32325031 ] [ RRC reference ]

Kim S, Sieburth D.
A Receptor Tyrosine Kinase Network Regulates Neuromuscular Function in Response to Oxidative Stress in Caenorhabditis elegans.
Genetics 2019 211(4) 1283-1295 
[ PubMed ID = 30782598 ] [ RRC reference ]

Chan JP, Sieburth D.
Localized sphingolipid signaling at presynaptic terminals is regulated by calcium influx and promotes recruitment of priming factors.
J Neurosci 2012 32(49) 17909-20 
[ PubMed ID = 23223309 ] [ RRC reference ]