分離済み変異体

tm1339

Allele Nametm1339
BalanceNot Required
OutCrossNot Accepted
Sequence NameY57A10A.25
Gene Nameparn-2
Worm BaseAllele Name tm1339
Gene Name parn-2
Sequence Y57A10A.25
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" homozygous viable
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 118692/118693-119231/119232 (539 bp deletion)
ChromosomeII
Putative gene structurecomplement(join(115592..115795, 116799..117336, 118590..119054, 119991..120256))
Map position7.39
Balancer
Map position of balancer
Sequence of primersExtFwd:AAGAGGCAGTCATTCTCGTC,IntFwd:GAATCCGCCACCGGCAGATA,ExtRev:GACGGGGACTCATCAACGAC,IntRev:CGCGCATACTAGGTATAGAA
Distributed lab
DepositorDr. S. Mitani
References Please submit your publication
Kow RL, Strovas TJ, McMillan PJ, Jacobi AM, Behlke MA, Saxton AD, Latimer CS, Keene CD, Kraemer BC.
Distinct Poly(A) nucleases have differential impact on sut-2 dependent tauopathy phenotypes.
Neurobiol Dis 2021 147 105148 
[ PubMed ID = 33184027 ] [ RRC reference ]

Nousch M, Yeroslaviz A, Eckmann CR.
Stage-specific combinations of opposing poly(A) modifying enzymes guide gene expression during early oogenesis.
Nucleic Acids Res 2019 47(20) 10881-10893 
[ PubMed ID = 31511882 ] [ RRC reference ]

Tang W, Tu S, Lee HC, Weng Z, Mello CC.
The RNase PARN-1 Trims piRNA 3' Ends to Promote Transcriptome Surveillance in C. elegans.
Cell 2016 164(5) 974-84 
[ PubMed ID = 26919432 ] [ RRC reference ]

Nousch M, Techritz N, Hampel D, Millonigg S, Eckmann CR.
The Ccr4-Not deadenylase complex constitutes the main poly(A) removal activity in C. elegans.
J Cell Sci 2013 126(Pt 18) 4274-85 
[ PubMed ID = 23843623 ] [ RRC reference ]