Home > 分離済み変異体 > tm1310

分離済み変異体

Allele Name		tm1310
Allele Type		バランス済
Sequence Name		C16A3.8
Gene Name		thoc-2
Worm Base	Allele Name	tm1310
	Gene Name	thoc-2
	Sequence	C16A3.8
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		lethal or sterile
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		1472/1473-2161/2162 (689 bp deletion)
Chromosome		III
Putative gene structure		join(45..140, 189..320, 522..613, 660..879, 1100..1282, 1333..1485, 1534..2038, 2267..2668, 2874..3801, 3850..3958, 4001..4139, 4188..5047, 5103..5483, 5550..5771)
Map position		-1.35
Balancer		hT2
Map position of balancer
Sequence of primers		IntRev:TTCCAAGAGCTTGCAGCCAA,ExtFwd:GCTTATGGAAGCAGCCGAGA,IntFwd:GCTCAGCGAATGAGAATGAA,ExtRev:GAGATCCAACCAGTGTTCCA
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Sun B, Sherrin M, Roy R. Unscheduled epigenetic modifications cause genome instability and sterility through aberrant R-loops following starvation. Nucleic Acids Res 2023 51(1) 84-98  [ PubMed ID = 36504323 ] [ RRC reference ] Castellano-Pozo M, García-Muse T, Aguilera A. The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development. PLoS One 2012 7(12) e52447  [ PubMed ID = 23285047 ] [ RRC reference ] Castellano-Pozo M, García-Muse T, Aguilera A. R-loops cause replication impairment and genome instability during meiosis. EMBO Rep 2012 13(10) 923-9  [ PubMed ID = 22878416 ] [ RRC reference ] Castellano-Pozo M, Santos-Pereira JM, Rondón AG, Barroso S, Andújar E, Pérez-Alegre M, García-Muse T, Aguilera A. R loops are linked to histone H3 S10 phosphorylation and chromatin condensation. Mol Cell 2013 52(4) 583-90  [ PubMed ID = 24211264 ] [ RRC reference ]