Home > 分離済み変異体 > tm1233

分離済み変異体

Allele Name		tm1233
Balance		Not Required
OutCross		Not Accepted
Sequence Name		F42A6.9
Gene Name		elks-1
Worm Base	Allele Name	tm1233
	Gene Name	elks-1
	Sequence	F42A6.9
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable. Dr. K. Shen: HSN presynaptic vesicle localization normal. HSN presynaptic components (syd-2, syd-1, GIT-1, SAD-1) localization normal. Dr. Y. Jin: same as reported by Denken et al.(2005). Dr. M. Zhen: no SYD-2::GFP localization defects in GABAergic neurons. Dr. C. Bargmann: locomotion OK, normal GFP::UNC-2 localization.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		27776/27777-28341/28342 (565 bp deletion)
Chromosome		IV
Putative gene structure		complement(join(24955..25102, 25160..25275, 26060..26429, 26702..27734, 28115..28223, 28272..28460))
Map position		-4.61
Balancer
Map position of balancer
Sequence of primers		ExtRev:GCCTACCTGGGATGATACGA,IntRev:CTGGGATGATACGATGGTCT,ExtFwd:CTCGTCTCAGCTCATCGGTA,IntFwd:CAGCTCATCGGTACCCTTGT
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Frankel EB, Tiroumalechetty A, Su Z, Henry PS, Mueller BD, Jorgensen EM, Wu Y, Kurshan PT. Intracellular protein-lipid interactions drive presynaptic assembly prior to neurexin recruitment. Neuron 2025 113(5) 737-753.e6  [ PubMed ID = 39814011 ] [ RRC reference ] Chia PH, Patel MR, Shen K. NAB-1 instructs synapse assembly by linking adhesion molecules and F-actin to active zone proteins. Nat Neurosci 2012 15(2) 234-42  [ PubMed ID = 22231427 ] [ RRC reference ] Saheki Y, Bargmann CI. Presynaptic CaV2 calcium channel traffic requires CALF-1 and the alpha(2)delta subunit UNC-36. Nat Neurosci 2009 12(10) 1257-65  [ PubMed ID = 19718034 ] [ RRC reference ] Patel MR, Shen K. RSY-1 is a local inhibitor of presynaptic assembly in C. elegans. Science 2009 323(5920) 1500-3  [ PubMed ID = 19286562 ] [ RRC reference ] Patel MR, Lehrman EK, Poon VY, Crump JG, Zhen M, Bargmann CI, Shen K. Hierarchical assembly of presynaptic components in defined C. elegans synapses. Nat Neurosci 2006 9(12) 1488-98  [ PubMed ID = 17115039 ] [ RRC reference ]