Home > 分離済み変異体 > tm1183

分離済み変異体

Allele Name		tm1183
Balance		Not Required
OutCross		Not Accepted
Sequence Name		F56A3.5
Gene Name		bro-1
Worm Base	Allele Name	tm1183
	Gene Name	bro-1
	Sequence	F56A3.5
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		16215/16216-16981/16982 (766 bp deletion)
Chromosome		I
Putative gene structure		join(15956..16120, 16553..16618, 17360..17587)
Map position		-0.3
Balancer
Map position of balancer
Sequence of primers		ExtRev:CCGTTCAATTCACGAAGCAT,IntRev:GGACCTGCGAGTTGTAACAA,IntFwd:CCGACAACATTTGTCGGTGA,ExtFwd:TTCTTGTGACTCCGCCTCCT
Distributed lab
Depositor		Dr. S. Mitani
References		Please submit your publication van der Horst SEM, Cravo J, Woollard A, Teapal J, van den Heuvel S. C. elegans Runx/CBFβ suppresses POP-1 TCF to convert asymmetric to proliferative division of stem cell-like seam cells. Development 2019 146(22)   [ PubMed ID = 31740621 ] [ RRC reference ] Robinson SB, Refai O, Hardaway JA, Sturgeon S, Popay T, Bermingham DP, Freeman P, Wright J, Blakely RD. Dopamine-dependent, swimming-induced paralysis arises as a consequence of loss of function mutations in the RUNX transcription factor RNT-1. PLoS One 2019 14(5) e0216417  [ PubMed ID = 31083672 ] [ RRC reference ] Hughes S, Brabin C, Appleford PJ, Woollard A. CEH-20/Pbx and UNC-62/Meis function upstream of rnt-1/Runx to regulate asymmetric divisions of the C. elegans stem-like seam cells. Biol Open 2013 2(7) 718-27  [ PubMed ID = 23862020 ] [ RRC reference ] Hajduskova M, Jindra M, Herman MA, Asahina M. The nuclear receptor NHR-25 cooperates with the Wnt/beta-catenin asymmetry pathway to control differentiation of the T seam cell in C. elegans. J Cell Sci 2009 122(Pt 17) 3051-60  [ PubMed ID = 19654209 ] [ RRC reference ] Kagoshima H, Nimmo R, Saad N, Tanaka J, Miwa Y, Mitani S, Kohara Y, Woollard A. The C. elegans CBFbeta homologue BRO-1 interacts with the Runx factor, RNT-1, to promote stem cell proliferation and self-renewal. Development 2007 134(21) 3905-15  [ PubMed ID = 17933794 ] [ RRC reference ]