分離済み変異体

tm1153

Allele Name

tm1153

Balance

Not Required

OutCross

Not Accepted

Sequence Name

F45E6.2

Gene Name

atf-6

Worm Base

Allele Name

tm1153

Gene Name

atf-6

Sequence

F45E6.2

Phenotype

homozygous viable

Mutation site

11879/11880-12522/12523 (643 bp deletion)

Chromosome

Putative gene structure

join(10548..10640, 10697..10888, 11181..11456, 11505..11675, 11726..11902, 11951..12190, 12237..12322, 12372..12602, 12835..13051, 13786..13872)

Map position

7.11

Balancer

Map position of balancer

Sequence of primers

IntRev:GTGCCCATTCGTGTCATTAT,ExtRev:ACGTCGGTAGTGTGCCCATT,IntFwd:CCGCCGCAATTTGACCAGCT,ExtFwd:TCCTTAATCGTCTTGCCCTC

Distributed lab

Depositor

Dr. S. Mitani

References

Please submit your publication

Tataridas-Pallas N, Aman Y, Williams R, Chapman H, Cheng KJH, Gomez-Paredes C, Bates GP, Labbadia J.
Mitochondrial clearance and increased HSF-1 activity are coupled to promote longevity in fasted Caenorhabditis elegans.
iScience 2024 27(6) 109834
[ PubMed ID = 38784016 ] [ RRC reference ]

Guan L, Zhan Z, Yang Y, Miao Y, Huang X, Ding M.
Alleviating chronic ER stress by p38-Ire1-Xbp1 pathway and insulin-associated autophagy in C. elegans neurons.
PLoS Genet 2020 16(9) e1008704
[ PubMed ID = 32986702 ] [ RRC reference ]

Waldherr SM, Strovas TJ, Vadset TA, Liachko NF, Kraemer BC.
Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau.
Nat Commun 2019 10(1) 4443
[ PubMed ID = 31570707 ] [ RRC reference ]

Sakaki K, Yoshina S, Shen X, Han J, DeSantis MR, Xiong M, Mitani S, Kaufman RJ.
RNA surveillance is required for endoplasmic reticulum homeostasis.
Proc Natl Acad Sci U S A 2012 109(21) 8079-84
[ PubMed ID = 22562797 ] [ RRC reference ]

Mao XR, Crowder CM.
Protein misfolding induces hypoxic preconditioning via a subset of the unfolded protein response machinery.
Mol Cell Biol 2010 30(21) 5033-42
[ PubMed ID = 20733002 ] [ RRC reference ]