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分離済み変異体

Allele Name		tm1095
Balance		Not Required
OutCross		Not Accepted
Sequence Name		K02B12.4
Gene Name		axl-1
Worm Base	Allele Name	tm1095
	Gene Name	axl-1
	Sequence	K02B12.4
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable. Dr. H.C. Korswagen: enhances the pry-1 (mu38) phenotype, axon guidance and excretory cell developmental defect. Dr. H. Sawa: not Psa but enhanced pry-1 Muv, PVul. Dr. S. Shaham: no obvious defects in glia development.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		22907/22908-23524/23525 (617 bp deletion)
Chromosome		I
Putative gene structure		join(22267..22332, 22971..23020, 23130..23255, 23299..23463, 23734..23810, 23859..23943, 23991..24150)
Map position		2.89
Balancer
Map position of balancer
Sequence of primers		IntRev:CCCGTTGTTTGTTCCCGTAA,ExtFwd:CTACCCCACTTGCCATACTT,IntFwd:CGTTTTTCCGTAGAACCGCA,ExtRev:ATCTTTGCCACCATCGGAAC
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Park EC, Rongo C. RPM-1 and DLK-1 regulate pioneer axon outgrowth by controlling Wnt signaling. Development 2018 145(18)   [ PubMed ID = 30093552 ] [ RRC reference ] Liu H, Dowdle JA, Khurshid S, Sullivan NJ, Bertos N, Rambani K, Mair M, Daniel P, Wheeler E, Tang X, Toth K, Lause M, Harrigan ME, Eiring K, Sullivan C, Sullivan MJ, Chang SW, Srivastava S, Conway JS, Kladney R, McElroy J, Bae S, Lu Y, Tofigh A, Saleh SMI, Fernandez SA, Parvin JD, Coppola V, Macrae ER, Majumder S, Shapiro CL, Yee LD, Ramaswamy B, Hallett M, Ostrowski MC, Park M, Chamberlin HM, Leone G. Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation. Dev Cell 2017 41(4) 392-407.e6  [ PubMed ID = 28535374 ] [ RRC reference ] Oosterveen T, Coudreuse DY, Yang PT, Fraser E, Bergsma J, Dale TC, Korswagen HC. Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans. Dev Biol 2007 308(2) 438-48  [ PubMed ID = 17601533 ] [ RRC reference ]