Home > 分離済み変異体 > tm1060

分離済み変異体

Allele Name		tm1060
Balance		Not Required
OutCross		Not Accepted
Sequence Name		F58G6.1
Gene Name		amph-1
Worm Base	Allele Name	tm1060
	Gene Name	amph-1
	Sequence	F58G6.1
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable. Dr. A. Fraser: synthetic embryonic lethal with T06G6.9 (RNAi), F21C3.5 (RNAi) and R151.9 (RNAi). D. Z. Zhou: no engulfment defect in embryos and hermaphrodite gonad. Dr. O. Blacque: Dyf (+), wild-type localization of ODR-10 to AWB cilium.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		7601/7602-8049/8050 (448 bp deletion)
Chromosome		IV
Putative gene structure		complement(join(4939..5253, 5597..5662, 5746..5844, 6129..6221, 6271..6426, 6808..6906, 6955..7041, 7198..7278, 7327..7428, 7476..7592, 7728..7841, 7887..7943))
Map position		4.35
Balancer
Map position of balancer
Sequence of primers		IntFwd:CGAGCAACTCTCAAATAGTC,ExtFwd:GAGTGAGAGCTCGGGCTTCA,ExtRev:GTTCCAGCTGAGAGGGCGTT,IntRev:TAATCGCTTACTCTCGGCCT
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication D'Alessandro M, Hnia K, Gache V, Koch C, Gavriilidis C, Rodriguez D, Nicot AS, Romero NB, Schwab Y, Gomes E, Labouesse M, Laporte J. Amphiphysin 2 Orchestrates Nucleus Positioning and Shape by Linking the Nuclear Envelope to the Actin and Microtubule Cytoskeleton. Dev Cell 2015 35(2) 186-98  [ PubMed ID = 26506308 ] [ RRC reference ] Liu O, Grant BD. Basolateral Endocytic Recycling Requires RAB-10 and AMPH-1 Mediated Recruitment of RAB-5 GAP TBC-2 to Endosomes. PLoS Genet 2015 11(9) e1005514  [ PubMed ID = 26393361 ] [ RRC reference ] Pant S, Sharma M, Patel K, Caplan S, Carr CM, Grant BD. AMPH-1/Amphiphysin/Bin1 functions with RME-1/Ehd1 in endocytic recycling. Nat Cell Biol 2009 11(12) 1399-410  [ PubMed ID = 19915558 ] [ RRC reference ]