分離済み変異体

tm1049

Allele Name

tm1049

Balance

Not Required

OutCross

Not Accepted

Sequence Name

C10C6.1

Gene Name

kin-4

Worm Base

Allele Name

tm1049

Gene Name

kin-4

Sequence

C10C6.1

Phenotype

homozygous viable. Dr. K. Shen: Normal HSN vulval presynaptic vesicle clusters (unc-86::SNB-1::YFP), no obvious egg laying defects.

Mutation site

5784/5785-TTTTTTCTGTAAAAAAATTCAAAAAAATTCA-7256/7257 (1472 bp deletion + 31 bp insertion)

Chromosome

Putative gene structure

join(3680..3921, 3972..4248, 5463..5648, 6106..6319, 6367..6533, 6580..6950, 7003..7155, 7208..7346, 7392..7629, 7680..7831, 7877..8029, 8076..8522, 9034..9819, 9889..10157, 10576..10894)

Map position

4.98

Balancer

Map position of balancer

Sequence of primers

ExtFwd:ACACACGGCTCCCATCTGTT,IntFwd:GCTCCCATCTGTTTGCTTTG,ExtRev:CTGGATACTCGACGTCTTCA,IntRev:CGTACAGGATAATTCCGAGA

Distributed lab

Depositor

Dr. S. Mitani/NBRP

References

Please submit your publication

Roumbo L, Ossareh-Nazari B, Vigneron S, Stefani I, Van Hove L, Legros V, Chevreux G, Lacroix B, Castro A, Joly N, Lorca T, Pintard L.
The MAST kinase KIN-4 carries out mitotic entry functions of Greatwall in C. elegans.
EMBO J 2025 44(7) 1943-1974
[ PubMed ID = 39962268 ] [ RRC reference ]

Nakano S, Nakayama A, Kuroyanagi H, Yamashiro R, Tsukada Y, Mori I.
Genetic screens identified dual roles of microtubule-associated serine threonine kinase and CREB within a single thermosensory neuron in the regulation of Caenorhabditis elegans thermotaxis behavior.
G3 (Bethesda) 2022 12(11)
[ PubMed ID = 36102820 ] [ RRC reference ]

An SWA, Choi ES, Hwang W, Son HG, Yang JS, Seo K, Nam HJ, Nguyen NTH, Kim EJE, Suh BK, Kim Y, Nakano S, Ryu Y, Man Ha C, Mori I, Park SK, Yoo JY, Kim S, Lee SV.
KIN-4/MAST kinase promotes PTEN-mediated longevity of Caenorhabditis elegans via binding through a PDZ domain.
Aging Cell 2019 18(3) e12906
[ PubMed ID = 30773781 ] [ RRC reference ]